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   Articles with "stress mitochondrial" as a keyword



Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202403892

Abstract: Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form of cell death, is identified as a critical mechanism… read more here.

Keywords: disc degeneration; intervertebral disc; oxidative stress; mitochondrial dysfunction ... See more keywords

Regulatory Role of Tubulin Beta 1 in Oocyte Endoplasmic Reticulum Stress and Mitochondrial Integrity via Transforming Growth Factor‐β1 Signaling Pathway in Mice

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recommendations! Published in 2025 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.70042

Abstract: Enhancing the developmental competence and quality of oocytes cultured in vitro remains challenging, in part due to limited understanding of the structural and molecular regulators of oocyte maturation. Microtubules, as key components of the cytoskeleton,… read more here.

Keywords: role; stress; tubb1; mitochondrial integrity ... See more keywords

Verapamil attenuates scopolamine induced cognitive deficits by averting oxidative stress and mitochondrial injury – A potential therapeutic agent for Alzheimer’s Disease

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recommendations! Published in 2019 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-019-00498-x

Abstract: Alzheimer’s disease (AD) is a multifactorial disorder where amyloid beta (Aβ) plaques, Ca 2+ dysregulation, excessive oxidative stress, mitochondrial dysfunction and synaptic loss operate synergistically to bring about cholinergic deficits and dementia. New therapeutic interventions… read more here.

Keywords: alzheimer disease; stress mitochondrial; verapamil; oxidative stress ... See more keywords
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Oxidative stress and mitochondrial dysfunction involved in ammonia-induced nephrocyte necroptosis in chickens.

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recommendations! Published in 2020 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2020.110974

Abstract: Ammonia (NH3), an environmental pollutant, poses a serious threat to human and avian health. Although previous studies have showed that NH3 caused kidney injury, the molecular mechanisms of nephrotoxicity induced by NH3 remain unclear. To… read more here.

Keywords: nephrocyte necroptosis; stress mitochondrial; necroptosis; related genes ... See more keywords

Pirfenidone alleviates lipopolysaccharide-induced lung injury by accentuating BAP31 regulation of ER stress and mitochondrial injury.

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recommendations! Published in 2020 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2020.102464

Abstract: Pirfenidone has been widely used in the treatment of idiopathic pulmonary fibrosis (IPF). However, the role of pirfenidone in LPS-induced acute lung injury (ALI) remains unclear. This study aims to investigate the protective effects of… read more here.

Keywords: mitochondrial injury; stress mitochondrial; injury; pirfenidone ... See more keywords

SPOTting stress at the mitochondrial outer membrane.

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recommendations! Published in 2022 at "Molecular cell"

DOI: 10.1016/j.molcel.2022.02.030

Abstract: Li et al. (2022) discover that Toxoplasma infection triggers remodeling of the mitochondrial outer membrane through generation of a mitochondrial subdomain termed "structure positive for outer mitochondrial membrane" (SPOT). read more here.

Keywords: mitochondrial outer; stress mitochondrial; membrane; outer ... See more keywords

HIVAN associated tubular pathology with reference to ER stress, mitochondrial changes, and autophagy.

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recommendations! Published in 2019 at "Experimental and molecular pathology"

DOI: 10.1016/j.yexmp.2018.12.009

Abstract: Human immunodeficiency virus associated nephropathy (HIVAN) is a unique form of a renal parenchymal disorder. This disease and its characteristics can be accredited to incorporation of DNA and mRNA of human immunodeficiency virus type 1… read more here.

Keywords: changes autophagy; stress mitochondrial; pathology; mitochondrial changes ... See more keywords

Paeonol Improves Cardiac Remodelling in MI Mice by Suppressing NOX2 mRNA Expression to Mitigate Oxidative Stress and Mitochondrial Dysfunction

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recommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70563

Abstract: Myocardial infarction (MI), a primary contributor to mortality from cardiovascular diseases, continues to pose a significant challenge in clinical treatment. In this study, our objective was to investigate the cardioprotective effects of paeonol (PAE) on… read more here.

Keywords: nox2 mrna; oxidative stress; dysfunction; mrna expression ... See more keywords
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Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts

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recommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2020/9102012

Abstract: The widespread use of therapeutic glucocorticoids has increased the frequency of glucocorticoid-induced osteoporosis (GIOP). One of the potential pathological processes of GIOP is an increased level of oxidative stress and mitochondrial dysfunction, which eventually leads… read more here.

Keywords: glucocorticoid induced; mitochondrial dysfunction; stress mitochondrial; oxidative stress ... See more keywords

Identification of NDUFV2, NDUFS7, OPA1, and NDUFA1 as biomarkers for Alzheimer's disease: Insights from oxidative stress and mitochondrial dysfunction in the hippocampus

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recommendations! Published in 2025 at "Journal of Alzheimer's Disease"

DOI: 10.1177/13872877251339771

Abstract: Background Alzheimer's disease (AD) is characterized by amyloid-β deposits, neurofibrillary tangles, and hippocampal neurodegeneration, with oxidative stress and mitochondrial dysfunction playing critical roles in its pathogenesis. Identifying hub genes associated with these processes could advance… read more here.

Keywords: alzheimer disease; stress; oxidative stress; mitochondrial dysfunction ... See more keywords

Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in Microglia by Alleviating Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.

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recommendations! Published in 2024 at "Journal of integrative neuroscience"

DOI: 10.31083/j.jin2302026

Abstract: BACKGROUND Microglia-mediated neuroinflammation is a hallmark of neurodegeneration. Metabotropic glutamate receptor 8 (GRM8) has been reported to promote neuronal survival in neurodegenerative diseases, yet the effect of GRM8 on neuroinflammation is still unclear. Calcium overload-induced… read more here.

Keywords: receptor; bv2 cells; mitochondrial dysfunction; calcium ... See more keywords