Polyamine-Activated Carbonyl Stress Nanoplatform Synergistically Reverses Biofilm-Driven Immunosuppressive Microenvironment.
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DOI: 10.1021/acsnano.5c08038
Abstract: Polyamine metabolic dysregulation induced by implant-associated infections (IAIs) is a pivotal contributor to the formation of an immunosuppressive microenvironment. Excessive polyamines facilitate pathogen persistence by suppressing bacterial membrane lipid peroxidation (LPO) and enhancing DNA repair… read more here.
Keywords: stress nanoplatform; immunosuppressive microenvironment; polyamine; stress ... See more keywords