Data-mining technique identifies potential target proteins playing a dual role in inflammation and oxidative stress pathways in relation to atherosclerosis plaque development
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DOI: 10.1016/j.imu.2019.100278
Abstract: Abstract Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An underlying source of most CVDs is atherosclerosis. The scarcity of effective drugs, and the side effects of existing marketed drugs, necessitates the discovery… read more here.
Keywords: oxidative stress; inflammation oxidative; target proteins; stress ... See more keywords
Effects of Levosimendan on Inflammation and Oxidative Stress Pathways in a Lipopolysaccharide-Stimulated Human Endothelial Cell Model
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DOI: 10.1177/1099800419861694
Abstract: Levosimendan is a myocardial Ca2+ sensitizer and opener of ATP-dependent potassium channels with inotropic, vasodilating, and cardioprotective properties. It was originally developed for the treatment of acute decompensated heart failure, but its complex mechanism of… read more here.
Keywords: oxidative stress; endothelial cell; inflammation oxidative; cell ... See more keywords