The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200026
Abstract: The integrated stress response (ISR) is a key determinant of tumorigenesis in response to oncogenic forms of stress like genotoxic, proteotoxic and metabolic stress. ISR relies on the phosphorylation of the translation initiation factor eIF2… read more here.
Keywords: induction mutant; stress response; lung; response induction ... See more keywords
Fecundity compensation is dependent on the generalized stress response in a nematode host
Sign Up to like & getrecommendations! Published in 2019 at "Ecology and Evolution"
DOI: 10.1002/ece3.5704
Abstract: Abstract Background Fecundity compensation, increased offspring output following parasite exposure, is widely reported, but the underlying mechanisms remain unclear. General stress responses are linked to other indirect defenses against parasites, and therefore may be responsible.… read more here.
Keywords: fecundity compensation; compensation; stress response;
Patterns of stress response to foreign eggs by a rejecter host of an obligate avian brood parasite
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.9691
Abstract: Abstract One of the most effective defenses of avian hosts against obligate brood parasites is the ejection of parasitic eggs from the nests. Despite the clear fitness benefits of this behavior, individuals within so‐called “egg‐rejecter”… read more here.
Keywords: rejecter host; host; stress response; egg ... See more keywords
Harnessing the Integrated Stress Response to Counteract Metabolic Disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30152
Abstract: Over a decade ago, fibroblast growth factor 21 (FGF21) was identified as a novel regulator of metabolism (1). Since that time, accumulating data have substantiated the therapeutic potential of this hormone in counteracting metabolic disease.… read more here.
Keywords: metabolic disease; integrated stress; disease; stress response ... See more keywords
SUMO regulation of FKBP51 activity and the stress response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30411
Abstract: Glucocorticoids (GCs) actions are mostly mediated by the GC receptor (GR), a member of the nuclear receptor superfamily. Alterations of the GR activity have been associated to different diseases including mood disorders. FKBP51 is a GR… read more here.
Keywords: stress response; activity; regulation; fkbp51 ... See more keywords
Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23967
Abstract: Abnormal redox homeostasis and oxidative stress have been proposed to play a role in the etiology of several neuropsychiatric spectrum disorders. Emerging interest has recently focused on markers of oxidative stress and neuroinflammation in schizophrenic… read more here.
Keywords: hormesis cellular; neuroinflammation; stress; cellular stress ... See more keywords
Cellular stress response mechanisms as therapeutic targets of ginsenosides
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21450
Abstract: Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a… read more here.
Keywords: mechanisms therapeutic; stress; cellular stress; response mechanisms ... See more keywords
Stress response and influencing factors among fever outpatients and children's families during normalisation of the COVID‐19 epidemic: A cross‐sectional study
Sign Up to like & getrecommendations! Published in 2023 at "Nursing Open"
DOI: 10.1002/nop2.1580
Abstract: To examine the demographic characteristics associated with stress response of fever outpatients and children's families during normalisation of the COVID‐19 epidemic and to examine the relationship between stress response, coping style and resilience. read more here.
Keywords: stress response; families normalisation; children families; fever outpatients ... See more keywords
iTRAQ‐based proteomic analysis reveals proteins associated with cold stress response in two different populations of Manila clam (Ruditapes philippinarum)
Sign Up to like & getrecommendations! Published in 2023 at "PROTEOMICS"
DOI: 10.1002/pmic.202100396
Abstract: Water temperature is one of the key environmental factors for marine ectotherms and a change in temperature beyond and organism's capacity limits can cause a series of changes to physiological state and damage to the… read more here.
Keywords: itraq based; stress; cold stress; stress response ... See more keywords
An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response.
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DOI: 10.1007/978-1-0716-1975-9_1
Abstract: Phosphorylation of the translation initiation factor eIF2α is an adaptive signaling event that is essential for cell and organismal survival from yeast to humans. It is central to the integrated stress response (ISR) that maintains… read more here.
Keywords: stress response; eif2 phosphorylation; phosphorylation; overview methods ... See more keywords
The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8559-3_14
Abstract: The nematode Caenorhabditis elegans (C. elegans) has proven to be a powerful model organism for the study of many biological processes, with major implications for human health and disease. As progranulin is a pleiotropic, secreted… read more here.
Keywords: cell; stress response; caenorhabditis elegans;