ATF4-mediated stress response as a therapeutic vulnerability in chordoma.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70176
Abstract: Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor T-box transcription factor… read more here.
Keywords: stress response; atf4 mediated; chordoma; mediated stress ... See more keywords
High-Humidity Stress Response in Faba Bean Aphids (Megoura crassicauda): Insights From Transcriptomic Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.70106
Abstract: High-humidity environments can inhibit the reproduction of faba bean aphids (Megoura crassicauda), reduce their moisture content, and induce the emergence of long-winged aphids. However, little is currently known about the molecular mechanisms through which M.… read more here.
Keywords: high humidity; stress response; humidity stress; humidity ... See more keywords
The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200026
Abstract: The integrated stress response (ISR) is a key determinant of tumorigenesis in response to oncogenic forms of stress like genotoxic, proteotoxic and metabolic stress. ISR relies on the phosphorylation of the translation initiation factor eIF2… read more here.
Keywords: induction mutant; stress response; lung; response induction ... See more keywords
Local variation in stress response of juvenile anadromous brown trout, Salmo trutta
Sign Up to like & getrecommendations! Published in 2024 at "Ecology and Evolution"
DOI: 10.1002/ece3.11526
Abstract: Abstract Habitat fragmentation may cut off anadromous salmonids from parts of their potential native habitat and separate previously connected populations. Understanding the consequences of this is vital for fish management and prioritization of restoration activities.… read more here.
Keywords: juvenile anadromous; variation; stress; anadromous brown ... See more keywords
Fecundity compensation is dependent on the generalized stress response in a nematode host
Sign Up to like & getrecommendations! Published in 2019 at "Ecology and Evolution"
DOI: 10.1002/ece3.5704
Abstract: Abstract Background Fecundity compensation, increased offspring output following parasite exposure, is widely reported, but the underlying mechanisms remain unclear. General stress responses are linked to other indirect defenses against parasites, and therefore may be responsible.… read more here.
Keywords: fecundity compensation; compensation; stress response;
Patterns of stress response to foreign eggs by a rejecter host of an obligate avian brood parasite
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.9691
Abstract: Abstract One of the most effective defenses of avian hosts against obligate brood parasites is the ejection of parasitic eggs from the nests. Despite the clear fitness benefits of this behavior, individuals within so‐called “egg‐rejecter”… read more here.
Keywords: rejecter host; host; stress response; egg ... See more keywords
Harnessing the Integrated Stress Response to Counteract Metabolic Disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30152
Abstract: Over a decade ago, fibroblast growth factor 21 (FGF21) was identified as a novel regulator of metabolism (1). Since that time, accumulating data have substantiated the therapeutic potential of this hormone in counteracting metabolic disease.… read more here.
Keywords: metabolic disease; integrated stress; disease; stress response ... See more keywords
SUMO regulation of FKBP51 activity and the stress response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30411
Abstract: Glucocorticoids (GCs) actions are mostly mediated by the GC receptor (GR), a member of the nuclear receptor superfamily. Alterations of the GR activity have been associated to different diseases including mood disorders. FKBP51 is a GR… read more here.
Keywords: stress response; activity; regulation; fkbp51 ... See more keywords
Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23967
Abstract: Abnormal redox homeostasis and oxidative stress have been proposed to play a role in the etiology of several neuropsychiatric spectrum disorders. Emerging interest has recently focused on markers of oxidative stress and neuroinflammation in schizophrenic… read more here.
Keywords: hormesis cellular; neuroinflammation; stress; cellular stress ... See more keywords
Cellular stress response mechanisms as therapeutic targets of ginsenosides
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21450
Abstract: Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a… read more here.
Keywords: mechanisms therapeutic; stress; cellular stress; response mechanisms ... See more keywords
Stress response and influencing factors among fever outpatients and children's families during normalisation of the COVID‐19 epidemic: A cross‐sectional study
Sign Up to like & getrecommendations! Published in 2023 at "Nursing Open"
DOI: 10.1002/nop2.1580
Abstract: To examine the demographic characteristics associated with stress response of fever outpatients and children's families during normalisation of the COVID‐19 epidemic and to examine the relationship between stress response, coping style and resilience. read more here.
Keywords: stress response; families normalisation; children families; fever outpatients ... See more keywords