A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice
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DOI: 10.1038/s41598-017-05125-2
Abstract: Huntington’s disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3… read more here.
Keywords: repeat expansions; striatal cag; cag repeat; disease ... See more keywords