The striatal cholinergic system in l-dopa-induced dyskinesias
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1845-9
Abstract: Cholinergic signaling plays a key role in regulating striatal function. The principal source of acetylcholine in the striatum is the cholinergic interneurons which, although low in number, densely arborize to modulate striatal neurotransmission. This modulation… read more here.
Keywords: induced dyskinesias; dopa induced; cholinergic system; cholinergic ... See more keywords
A spotlight on the elusive striatal cholinergic interneuron
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abi4907
Abstract: A new role for the ubiquitous integrated stress response pathway in striatal-dependent learning and memory The brain of the mouse, one of the most commonly used animal models in biomedical research, is composed of about… read more here.
Keywords: elusive striatal; cholinergic interneuron; learning memory; striatal cholinergic ... See more keywords
17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.993552
Abstract: The striatum is an essential component of the basal ganglia that is involved in motor control, action selection and motor learning. The pathophysiological changes of the striatum are present in several neurological and psychiatric disorder… read more here.
Keywords: cholinergic neurons; adult mice; striatal cholinergic; effect ... See more keywords
Nanoscopic distribution of VAChT and VGLUT3 in striatal cholinergic varicosities suggests colocalization and segregation of the two transporters in synaptic vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.991732
Abstract: Striatal cholinergic interneurons (CINs) use acetylcholine (ACh) and glutamate (Glut) to regulate the striatal network since they express vesicular transporters for ACh (VAChT) and Glut (VGLUT3). However, whether ACh and Glut are released simultaneously and/or… read more here.
Keywords: striatal cholinergic; distribution vacht; vacht vglut3; cholinergic varicosities ... See more keywords
Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.56920
Abstract: Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to Parkinson’s disease pathophysiology and dyskinesia from chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, but the physiological basis of these changes is unknown. We find that dopamine… read more here.
Keywords: chronic dopa; alterations intrinsic; striatal cholinergic; dopamine lesion ... See more keywords