Striatal dopamine in Parkinson disease: A meta‐analysis of imaging studies
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.25103
Abstract: A meta‐analysis of 142 positron emission tomography and single photon emission computed tomography studies that have investigated striatal presynaptic dopamine function in Parkinson disease (PD) was performed. Subregional estimates of striatal dopamine metabolism are presented.… read more here.
Keywords: striatal dopamine; parkinson disease; disease; meta analysis ... See more keywords
Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26848
Abstract: The objective of this study was to investigate in vivo the ability of levodopa/carbidopa intestinal gel infusions to produce sustained striatal dopamine levels and to improve clinical outcomes in Parkinson's disease patients. read more here.
Keywords: disease patients; dopamine levels; striatal dopamine; sustained striatal ... See more keywords
Individual parkinsonian motor signs and striatal dopamine transporter deficiency: a study with [I-123]FP-CIT SPECT
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09202-6
Abstract: IntroductionTotal parkinsonian motor symptom severity correlates with presynaptic striatal dopamine function in patients with Parkinson’s disease. There is a lack of studies that have investigated the associations between parkinsonian motor signs and striatal dopaminergic deficiency… read more here.
Keywords: parkinsonian motor; motor signs; motor; striatal dopamine ... See more keywords
DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00830-4
Abstract: The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s)… read more here.
Keywords: ppn; cholinergic neurons; dopamine; striatal dopamine ... See more keywords
Striatal dopamine and the temporal control of behavior
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.08.030
Abstract: Striatal dopamine strongly regulates how individuals use time to guide behavior. Dopamine acts on D1- and D2- dopamine receptors in the striatum. However, the relative role of these receptors in the temporal control of behavior… read more here.
Keywords: control; dopamine temporal; temporal control; striatal dopamine ... See more keywords
Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105699
Abstract: Trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, is commonly used for the treatment of dystonia associated with TOR1A, otherwise known as DYT1 dystonia. A better understanding of the mechanism of action of THP is… read more here.
Keywords: tor1a dystonia; release; striatal dopamine; dopamine release ... See more keywords
The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.10.070
Abstract: A growing body of evidence indicates that impairment of the ubiquitin-proteasome (UPS) system in the substantia nigra (SN) plays an important role in the pathogenesis of Parkinson's disease (PD). The aim of our study was… read more here.
Keywords: study; lactacystin; sensitivity; rotational behavior ... See more keywords
Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.
Sign Up to like & getrecommendations! Published in 2023 at "Behavioral neuroscience"
DOI: 10.1037/bne0000547
Abstract: Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission… read more here.
Keywords: striatal dopamine; capacity; dopa pet; dopamine ... See more keywords
Parkinson disease
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Disease Primers"
DOI: 10.1038/nrdp.2017.13
Abstract: Parkinson disease is the second-most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of… read more here.
Keywords: striatal dopamine; motor; disease; parkinson disease ... See more keywords
The relationship between grey matter volume and striatal dopamine function in psychosis: a multi-modal 18F-DOPA PET and voxel-based morphometry study
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-019-0570-6
Abstract: A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. Although supported by preclinical… read more here.
Keywords: treatment; grey matter; volume; striatal dopamine ... See more keywords
T137. THE RELATIONSHIP BETWEEN CORTICOSTRIATAL CONNECTIVITY AND STRIATAL DOPAMINE FUNCTION IN SCHIZOPHRENIA: AN 18F-DOPA PET AND DIFFUSION TENSOR IMAGING STUDY
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa029.697
Abstract: Abstract Background Striatal dopamine dysfunction caused by cortical abnormalities is a leading hypothesis of schizophrenia pathophysiology, which underlies in majority of treatment-responsive patients. Although supported by findings that prefrontal cortical lesions lead to striatal dopamine… read more here.
Keywords: associative striatum; treatment; connectivity; striatal dopamine ... See more keywords