SA95 INDEPENDENT GENETIC EVIDENCE LINKS STRIATAL-ENRICHED PROTEIN TYROSINE PHOSPHATASE (STEP) TO HUMAN ATTENTION AND SCHIZOPHRENIA-RELATED TRAITS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.167
Abstract: Background Genetic association and protein expression findings in humans and observations in animal models, have implicated the STriatal-Enriched protein tyrosine Phosphatase (STEP) in cognitive functioning and schizophrenia. Methods Here, we aimed to confirm the association… read more here.
Keywords: striatal enriched; enriched protein; schizophrenia; step ... See more keywords
Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17192
Abstract: OBJECTIVE STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific tyrosine phosphatase. Membrane-bound STEP61 is the only isoform expressed in hippocampus and cortex. Genetic deletion of STEP enhances excitatory synaptic currents and long-term potentiation in the… read more here.
Keywords: seizure; striatal enriched; protein tyrosine; excitability ... See more keywords
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)
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DOI: 10.3390/ijms22094417
Abstract: Many human diseases are the result of abnormal expression or activation of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Not surprisingly, more than 30 tyrosine kinase inhibitors (TKIs) are currently in clinical use… read more here.
Keywords: striatal enriched; step; tyrosine; tyrosine phosphatase ... See more keywords