On‐Demand Chemomagnetic Modulation of Striatal Neurons Facilitated by Hybrid Magnetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202204732
Abstract: Minimally invasive manipulation of cell signaling is critical in basic neuroscience research and in developing therapies for neurological disorders. Here, a wireless chemomagnetic neuromodulation platform for the on‐demand control of primary striatal neurons that relies… read more here.
Keywords: hybrid magnetic; dopamine; poegma; magnetic nanoparticles ... See more keywords
Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3968-7
Abstract: Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and… read more here.
Keywords: neuroprotective effect; receptors cell; huntington disease; striatal neurons ... See more keywords
Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01734-2
Abstract: In the present study, we investigated whether mutant huntingtin (mHTT) impairs mitochondrial functions in human striatal neurons derived from induced pluripotent stem cells (iPSCs). Striatal neurons and astrocytes derived from iPSCs from unaffected individuals (Ctrl)… read more here.
Keywords: huntingtin; anion production; striatal neurons; superoxide anion ... See more keywords
Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.04.005
Abstract: In this issue of Neuron, Lahiri and Bevan (2020) investigate the effects of dopamine release on striatal projection neurons. Using perforated patch recordings and optogenetics, they show that dopamine release persistently enhances the intrinsic excitability… read more here.
Keywords: striatal neurons; pathway striatal; direct pathway; excitability direct ... See more keywords
G protein signaling–biased agonism at the κ-opioid receptor is maintained in striatal neurons
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aar4309
Abstract: Triazole 1.1 is a G protein–biased agonist of the κ-opioid receptor in striatal neurons. Biasing pain treatment against side effects Stimulating opioid receptors with targeted agonists can treat pain, but such drugs often cause unwanted… read more here.
Keywords: biased agonism; opioid receptor; striatal neurons; protein signaling ... See more keywords
Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666200217114658
Abstract: Parkinson's disease is a progressive neurodegenerative disorder of dopaminergic striatal neurons in basal ganglia. Treatment of Parkinson's disease (PD) through dopamine replacement strategies may provide improvement in early stages and this treatment response is related… read more here.
Keywords: striatal neurons; treatment; current therapeutic; parkinson disease ... See more keywords
Striatal D1 Dopamine Neuronal Population Dynamics in a Rat Model of Levodopa-Induced Dyskinesia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.783893
Abstract: Background The pathophysiology of levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) is not well understood. Experimental data from numerous investigations support the idea that aberrant activity of D1 dopamine receptor-positive medium spiny neurons in the… read more here.
Keywords: induced dyskinesia; neuronal population; lid rats; levodopa ... See more keywords
Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00547
Abstract: The striatum plays an important role in linking cortical activity to basal ganglia output. Striatal neurons exhibit spontaneous slow Ca2+ oscillations that result from Ca2+ release from the endoplasmic reticulum (ER) induced by the mGluR5-IP3R… read more here.
Keywords: store operated; striatal neurons; operated calcium; ca2 ... See more keywords
Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1014497
Abstract: Gintonin, a glycolipid protein conjugated with lysophosphatidic acid (LPA), is a newly identified compound extracted from Korean ginseng. LPA receptor isotypes exhibit high affinity for gintonin and mediate intracellular calcium signaling in various animal cell… read more here.
Keywords: dendritic growth; gintonin; striatal neurons; akt creb ... See more keywords
Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911054
Abstract: Since the discovery of striatal neurons expressing dopamine-synthesizing enzymes, researchers have attempted to identify their phenotype and functional significance. In this study, it was shown that in transgenic mice expressing green fluorescent protein (GFP) under… read more here.
Keywords: dopamine; neurons expressing; phenotype functional; functional significance ... See more keywords
Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076799
Abstract: The modeling of neuropathology on induced neurons obtained by cell reprogramming technologies can fill a gap between clinical trials and studies on model organisms for the development of treatment strategies for neurodegenerative diseases. Patient-specific models… read more here.
Keywords: reprogramming primary; optimization direct; direct reprogramming; protocol optimization ... See more keywords