The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice
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DOI: 10.1111/adb.12663
Abstract: Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2‐knockout mice have shown… read more here.
Keywords: addiction; per2; circadian gene; mice ... See more keywords
Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice
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DOI: 10.3390/ijms24065956
Abstract: Huntington’s disease is one of the most common dominantly inherited neurodegenerative disorders caused by an expansion of a polyglutamine (polyQ) stretch in the N-terminal region of huntingtin (Htt). Among all the molecular mechanisms, affected by… read more here.
Keywords: striatum mice; modulator thi; glycosphingolipid modulator; treatment glycosphingolipid ... See more keywords
Quantitation of the A2A Adenosine Receptor Density in the Striatum of Mice and Pigs with [18F]FLUDA by Positron Emission Tomography
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DOI: 10.3390/ph15050516
Abstract: The cerebral expression of the A2A adenosine receptor (A2AAR) is altered in neurodegenerative diseases such as Parkinson’s (PD) and Huntington’s (HD) diseases, making these receptors an attractive diagnostic and therapeutic target. We aimed to further… read more here.
Keywords: striatum mice; a2a adenosine; striatum; 18f fluda ... See more keywords