The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes
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DOI: 10.1371/journal.pgen.1008819
Abstract: The striatin-interacting phosphatase and kinase (STRIPAK) multi-subunit signaling complex is highly conserved within eukaryotes. In fungi, STRIPAK controls multicellular development, morphogenesis, pathogenicity, and cell-cell recognition, while in humans, certain diseases are related to this signaling… read more here.
Keywords: signaling complex; gul1; shuttles endosomes; phosphorylation ... See more keywords
Role of the STRIPAK complex and the Hippo pathway in synaptic terminal formation
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DOI: 10.4103/1673-5374.205089
Abstract: To transmit neural information from pre to postsynaptic neurons, the number, morphology, and function of the synapse have to be strictly regulated. Failures in synaptic formations are linked to neural disorders. For example, it is… read more here.
Keywords: strip; stripak complex; synapse formation; role ... See more keywords
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
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DOI: 10.7554/elife.53003
Abstract: Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST)… read more here.
Keywords: pp2a; transformation; pp2a subunits; cell transformation ... See more keywords
STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism
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DOI: 10.7554/elife.54863
Abstract: The MST-LATS kinase cascade is central to the Hippo pathway that controls tissue homeostasis, development, and organ size. The PP2A complex STRIPAKSLMAP blocks MST1/2 activation. The GCKIII family kinases associate with STRIPAK, but the functions… read more here.
Keywords: stripak; hippo signaling; stk25 suppresses; antagonism ... See more keywords