Embolic Stroke Model with Magnetic Nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c11377
Abstract: Stroke models are vital tools in neuropharmacology and rehabilitation research. However, a classic and widely used model-the suture occlusion model-is not suitable for all research approaches, especially regarding thrombolysis. For embolic stroke models in thrombolytic… read more here.
Keywords: research; artery; model; embolic stroke ... See more keywords
Validation of a stroke model in rat compatible with rt-PA-induced thrombolysis: new hope for successful translation to the clinic
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69081-0
Abstract: The recent clinical trial (DAWN) suggests that recanalization treatment may be beneficial up to 24 h after stroke onset, thus re-opening avenues for development of new therapeutic strategies. Unfortunately, there is a continuous failure of… read more here.
Keywords: model rat; validation stroke; model; stroke onset ... See more keywords
Evaluation of anti-inflammatory diphenyldihaloketone EF24 in transient ischemic stroke model
Sign Up to like & getrecommendations! Published in 2022 at "Brain Injury"
DOI: 10.1080/02699052.2022.2034959
Abstract: ABSTRACT Objectives Revascularization is necessary in patients with ischemic stroke, however it does not address inflammation that contribute to reperfusion injury and the early growth of ischemic core. We investigated EF24, an anti-inflammatory agent, in… read more here.
Keywords: ef24; stroke model; anti inflammatory; stroke ... See more keywords
Bidirectional Return-Stroke Model for the Calculation of Lightning Electromagnetic Fields
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Electromagnetic Compatibility"
DOI: 10.1109/temc.2020.2981149
Abstract: This article focuses on the bidirectional return-stroke propagation phenomenon in the initiation process of lightning return stroke. Different from the conventional return-stroke model, the return-stroke current waves in the bidirectional return-stroke model are considered to… read more here.
Keywords: return; calculation; bidirectional return; return stroke ... See more keywords
In vivo tissue optical clearing assisted through-skull targeted photothrombotic ischemic stroke model in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Optics"
DOI: 10.1117/1.jbo.27.6.065001
Abstract: Abstract. Significance: Photothrombotic stroke is an important and widely used model for ischemic stroke research. However, the significant scattering of the skull during the procedure limits the light’s ability to penetrate and focus on its… read more here.
Keywords: optical clearing; ischemic stroke; model; stroke model ... See more keywords
What to do about fibrin rich ‘tough clots’? Comparing the Solitaire stent retriever with a novel geometric clot extractor in an in vitro stroke model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/neurintsurg-2017-013507
Abstract: Background Despite advances in revascularization tools for large vessel occlusion presenting as acute ischemic stroke, a significant subset of clots remain recalcitrant to current strategies. We assessed the effectiveness of a novel thrombectomy device that… read more here.
Keywords: geometric clot; fibrin rich; stroke model; fibrin ... See more keywords
Establishment of a reproducible and minimally invasive ischemic stroke model in swine.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.163398
Abstract: The need for advances in the management/treatment options for ischemic stroke patients requires that upcoming preclinical research uses animals with more human-like brain characteristics. The porcine brain is considered appropriate, although the presence of the… read more here.
Keywords: reproducible minimally; stroke model; model; minimally invasive ... See more keywords
Quantitative behavioral evaluation of a non-human primate stroke model using a new monitoring system
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.964928
Abstract: Background Recently, the common marmoset (Callithrix jacchus) has attracted significant interest as a non-human primate stroke model. Functional impairment in non-human primate stroke models should be evaluated quantitatively and successively after stroke, but conventional observational… read more here.
Keywords: primate stroke; human primate; stroke model; non human ... See more keywords
A Novel Improved Thromboembolism-Based Rat Stroke Model That Meets the Latest Standards in Preclinical Studies
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12121671
Abstract: The animal thromboembolic model of ischemia perfectly mimics human ischemic stroke which remains the leading cause of disability and mortality in humans. The development of new treatment strategies was therefore imperative. The purpose of this… read more here.
Keywords: improved thromboembolism; motor; model; novel improved ... See more keywords
Isosteviol Sodium (STVNA) Reduces Pro-Inflammatory Cytokine IL-6 and GM-CSF in an In Vitro Murine Stroke Model of the Blood–Brain Barrier (BBB)
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091753
Abstract: Early treatment with glucocorticoids could help reduce both cytotoxic and vasogenic edema, leading to improved clinical outcome after stroke. In our previous study, isosteviol sodium (STVNA) demonstrated neuroprotective effects in an in vitro stroke model,… read more here.
Keywords: stvna; isosteviol sodium; sodium stvna; blood brain ... See more keywords
Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Stem Cells"
DOI: 10.4252/wjsc.v11.i2.100
Abstract: BACKGROUND Mesenchymal stem cells (MSCs) have been widely tested for their therapeutic efficacy in the ischemic brain and have been shown to provide several benefits. A major obstacle to the clinical translation of these therapies… read more here.
Keywords: hbm; triple modal; multimodal nanoparticles; stem ... See more keywords