Apremilast exerts protective effects on stroke outcomes and blood–brain barrier (BBB) dysfunction through regulating Rho‐associated protein kinase 2 expression
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DOI: 10.1002/brb3.2677
Abstract: Stroke is a devastating event and a huge public health concern worldwide. Apremilast (APR) is a selective inhibitor of phosphodiesterase‐4 involved in various neurological diseases, including stroke. However, the protective effects of APR on stroke… read more here.
Keywords: protective effects; blood brain; brain barrier; brain ... See more keywords
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant.
Sign Up to like & getrecommendations! Published in 2021 at "Translational stroke research"
DOI: 10.1007/s12975-021-00945-x
Abstract: MicroRNAs have gained popularity as a potential treatment for many diseases, including stroke. This study identifies and characterizes a specific member of the miR-17-92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening… read more here.
Keywords: mir 20a; sensory motor; treatment; stroke outcomes ... See more keywords
Blood pressure undulation of peripheral thrombolysis period in acute ischemic stroke is associated with prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003070
Abstract: Background: Evidence suggests that patients with higher blood pressure variability (BPV) have a higher risk for stroke but the relationship between BPV and stroke outcomes is unknown in those who underwent intravenous thrombolysis (IVT) for… read more here.
Keywords: prior ivt; risk; ivt ivt; stroke outcomes ... See more keywords
Quality of care for better stroke outcomes . . . and other stories
Sign Up to like & getrecommendations! Published in 2017 at "British Medical Journal"
DOI: 10.1136/bmj.j1344
Abstract: Routine testing for Chlamydia trachomatis in pregnant women in Finland, using urine nucleic acid amplification tests, shows a carriage rate of 2.7%. Textbooks and guidelines claim that half of the babies born to infected women… read more here.
Keywords: better stroke; care better; stroke outcomes; quality care ... See more keywords
Gender Differences and Stroke Outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Neuroepidemiology"
DOI: 10.1159/000475451
Abstract: ICAS in the Asian population [7] . Variations in risk factors among populations from different countries may explain differences in the ICAS incidence. The high rate in Japanese population is attributed to the high frequency… read more here.
Keywords: gender differences; stroke outcomes; differences stroke; symptomatic icas ... See more keywords
Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.121.318897
Abstract: Supplemental Digital Content is available in the text. Rationale: The systemic inflammatory milieu plays an important role in the age-related decline in functional integrity, but its contribution to age-related disease (eg, stroke) remains largely unknown.… read more here.
Keywords: serum exosomes; stroke; exosomes aged; stroke outcomes ... See more keywords
Abstract WMP90: Marital Status and Post-Stroke Outcomes
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DOI: 10.1161/str.51.suppl_1.wmp90
Abstract: Introduction: Although the impacts of marital status on health have long been recognized, little is known about its role in stroke outcomes. The study examined the association of marital status with neuropsychiatric, cognitive, functional, and… read more here.
Keywords: status; quality life; marital status; stroke outcomes ... See more keywords
Polypill: Benefits Seen for Stroke and Other Outcomes
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DOI: 10.1161/strokeaha.122.037313
Abstract: A polypill-type strategy for primary prevention was first published at the turn of the century and advised that a multi-ingredient pill applied to an adult population would prevent up to 80% of cardiovascular and stroke… read more here.
Keywords: polypill benefits; prevention; benefits seen; seen stroke ... See more keywords
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s148073
Abstract: Background Stroke has high mortality and morbidity. Biomarkers are required for to predict stroke outcomes, which could help clinicians to provide rationale approaches for patient management. The dynamic changes in circulating immune cells have been… read more here.
Keywords: frequencies circulating; stroke outcomes; stroke patients; immune cells ... See more keywords
Evaluating the comorbidities of age and cigarette smoking on stroke outcomes in the context of anti-complement mitigation strategies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1161051
Abstract: Multiple neuroprotective agents have shown beneficial effects in rodent models of stroke, but they have failed to translate in the clinic. In this perspective, we consider that a likely explanation for this failure, at least… read more here.
Keywords: stroke outcomes; age cigarette; cigarette smoking; age ... See more keywords
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats
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DOI: 10.3390/brainsci12010035
Abstract: Aim: Nuclear factor kappa B (NF-κB) is known to play an important role in the inflammatory process which takes place after ischemic stroke. The major objective of the present study was to examine the effects… read more here.
Keywords: severity adverse; post ischemic; stroke; stroke outcomes ... See more keywords