Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135296
Abstract: BACKGROUND Ischemic stroke is one of the leading causes of mortality and morbidity. The currently available non-invasive therapeutic options are not sufficiently efficacious. Post-ischemic brain is characterized by a prominent inflammatory response. Little is known… read more here.
Keywords: ischemic stroke; mortality; post mcao; stroke rats ... See more keywords
Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3β/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00844-9
Abstract: Stroke is the major cause of death and disability worldwide. Most stroke patients who survive in the acute phase of ischemia display various extents of neurological deficits. In order to improve the prognosis of ischemic… read more here.
Keywords: stroke rats; neurogenesis; endogenous neurogenesis; administration ... See more keywords
3,6′- and 1,6′-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050950
Abstract: (1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tolerated analogs may provide a… read more here.
Keywords: inflammation; mitigate ischemic; stroke rats; stroke ... See more keywords