Trends in Recruitment Rates for Acute Stroke Trials, 1990–2014
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DOI: 10.1161/strokeaha.116.014458
Abstract: Background and Purpose— Slow recruitment in acute stroke trials hampers the evaluation of new therapies and delays the adoption of effective therapies into clinical practice. This systematic review evaluates whether recruitment efficiency and rates have… read more here.
Keywords: stroke trials; recruitment rates; acute stroke; trials 1990 ... See more keywords
Letter by Murray and Barrow Regarding Article, "Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014".
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DOI: 10.1161/strokeaha.117.017121
Abstract: The article by Feldman et al1 discussing trends and difficulties in recruitment for stroke trials was read with a great deal of interest. Although difficulties of recruitment into stroke trials are multifactorial, there has been… read more here.
Keywords: stroke trials; article; murray barrow; acute stroke ... See more keywords
Response by Feldman et al to Letter Regarding Article, "Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014".
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DOI: 10.1161/strokeaha.117.017210
Abstract: We thank Murray and Barrow for their response to our article, Trends in Recruitment Rates for Acute Stroke Trials, 1990–2014.1 We agree that one contributing factor to slow recruitment in acute stroke trials is the… read more here.
Keywords: stroke trials; recruitment rates; trends recruitment; acute stroke ... See more keywords
Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials.
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DOI: 10.1161/strokeaha.117.017866
Abstract: Who would have guessed that a scale introduced by Dr John Rankin in 1957 would become the primary outcome scale for almost all acute stroke trials?1 The Rankin Scale was modified to its current form… read more here.
Keywords: stroke trials; mrs; rankin scale; stroke ... See more keywords
Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis.
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DOI: 10.1161/strokeaha.119.025019
Abstract: Background and Purpose- In randomized stroke trials, central adjudication of a trial's primary outcome is regularly implemented. However, recent evidence questions the importance of central adjudication in randomized trials. The aim of this review was… read more here.
Keywords: site investigators; central adjudicators; adjudication; site ... See more keywords
Trials in Sleep Apnea and Stroke
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DOI: 10.1161/strokeaha.120.031709
Abstract: Few randomized controlled trials have evaluated the effectiveness of continuous positive airway pressure (CPAP) in reducing recurrent vascular events and mortality in poststroke obstructive sleep apnea (OSA). To date, results have been mixed, most studies… read more here.
Keywords: sleep apnea; apnea stroke; cpap; trials sleep ... See more keywords
Distribution-Free Approach to the Design and Analysis of Randomized Stroke Trials With the Modified Rankin Scale
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DOI: 10.1161/strokeaha.121.037744
Abstract: Background: Many methods have been suggested for analyzing the modified Rankin Scale (mRS). However, there lacks a unified approach to analysis and sample size determination that properly uses the ordinal nature of the data. We… read more here.
Keywords: stroke trials; rankin scale; modified rankin; analysis randomized ... See more keywords
Recruitment in Acute Stroke Trials: Challenges and Potential Solutions.
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DOI: 10.1161/strokeaha.122.040071
Abstract: Randomized clinical trials of acute stroke have led to major advances in acute stroke therapy over the past decade. Despite these successes, recruitment in acute trials is often difficult. We outline challenges in recruitment for… read more here.
Keywords: stroke trials; potential solutions; recruitment acute; acute stroke ... See more keywords
Are People with Aphasia Included in Stroke Trials? A Systematic Review and Narrative Synthesis.
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DOI: 10.1177/02692155231172009
Abstract: OBJECTIVE To examine the proportion of people with aphasia (PwA) included and retained in randomised controlled trials (RCTs) of stroke interventions published in the previous 6 years, as well as aphasia-relevant eligibility criteria and inclusion/retention… read more here.
Keywords: stroke trials; included stroke; review; people aphasia ... See more keywords
Cost-benefit of outcome adjudication in nine randomised stroke trials
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DOI: 10.1177/1740774520939231
Abstract: Background Central adjudication of outcomes is common for randomised trials and should control for differential misclassification. However, few studies have estimated the cost of the adjudication process. Methods We estimated the cost of adjudicating the… read more here.
Keywords: stroke trials; randomised stroke; adjudication; nine randomised ... See more keywords
Should we adjudicate outcomes in stroke trials? A systematic review
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DOI: 10.1177/17474930221094682
Abstract: Background: Central adjudication of outcomes is common in randomized clinical trials in stroke. The rationale for adjudication is clear; centrally adjudicated outcomes should have less random and systematic errors than outcomes assessed locally by site… read more here.
Keywords: stroke trials; adjudicate outcomes; adjudication may; review ... See more keywords