High stroma‐derived WNT5A is an indicator for low‐risk prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13131
Abstract: Prostate cancer (PCa) is a major cause of cancer‐related death in men. Tumor‐derived protein derived from Wnt5A gene (WNT5A) plays an important role in primary and metastatic PCa. Surrounding stroma cells also produce WNT5A, which… read more here.
Keywords: risk; stroma derived; high risk; derived wnt5a ... See more keywords
Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-40146-7_6
Abstract: The tumor microenvironment (TME) is rich in matrix components, growth factors, cytokines, and enzymatic modifiers that respond to changing conditions, to alter the fundamental properties of the tumor bed. Perlecan/HSPG2, a large, multi-domain heparan sulfate… read more here.
Keywords: perlecan modifiers; stroma; influence; tumor microenvironment ... See more keywords
3D is not enough: Building up a cell instructive microenvironment for tumoral stroma microtissues.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2016.10.007
Abstract: We fabricated three-dimensional microtissues with the aim to replicate in vitro the composition and the functionalities of the tumor microenvironment. By arranging either normal fibroblasts (NF) or cancer-activated fibroblasts (CAF) in two different three dimensional… read more here.
Keywords: cancer activated; stroma; vitro; cell ... See more keywords
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.09.001
Abstract: Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we… read more here.
Keywords: vulnerability p62; synthetic vulnerability; stroma; p62 deficient ... See more keywords
Correlation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2020.109345
Abstract: OBJECTIVE This study evaluated the correlation between intratumoural stroma proportion, expressed as tumour-stroma ratio (TSR), and apparent diffusion coefficient (ADC) values in patients with rectal cancer. METHODS This multicentre retrospective study included all consecutive patients… read more here.
Keywords: correlation; stroma; rectal cancer; adc values ... See more keywords
Permeability of the porcine iris stroma
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.005
Abstract: ABSTRACT Current literature has not considered or provided any data on the permeability of the iris stroma. In this study, we aimed to determine the hydraulic permeability of porcine irides from the isolated stroma. Fifteen… read more here.
Keywords: stroma; porcine iris; permeability porcine; iris stroma ... See more keywords
Development and Validation of a Quantitative Reactive Stroma Biomarker (qRS) for Prostate Cancer Prognosis.
Sign Up to like & getrecommendations! Published in 2022 at "Human pathology"
DOI: 10.1016/j.humpath.2022.01.009
Abstract: PURPOSE To develop and validate a new tissue-based biomarker that improves prediction of outcomes in localized prostate cancer by quantifying the host response to tumor. MATERIALS AND METHODS We use digital image analysis and machine… read more here.
Keywords: biomarker; qrs; stroma; prostate ... See more keywords
Evolution of the vertebrate corneal stroma
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2018.01.002
Abstract: Although the cornea is the major refractive element of the eye, the mechanisms controlling corneal shape and hence visual acuity remain unknown. To begin to address this question we have used multiphoton, non-linear optical microscopy… read more here.
Keywords: collagen; evolution vertebrate; corneal stroma; stroma ... See more keywords
Papillary thyroid carcinoma with nodular fasciitis-like stroma and β-catenin mutations should be renamed papillary thyroid carcinoma with desmoid-type fibromatosis
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.173
Abstract: Various histological variants of papillary thyroid carcinoma have been reported, some with clinical implications, some with peculiar, sometimes misleading morphologies. One of these rare and poorly characterized variants is papillary thyroid carcinoma with nodular fasciitis-like… read more here.
Keywords: papillary thyroid; stroma; thyroid carcinoma; nodular fasciitis ... See more keywords
Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.219
Abstract: Epithelial ovarian tumors are responsive to steroid hormone stimulation and the ovarian stroma may have a direct role in this process. We evaluated immunohistochemical markers of sex-steroid differentiation and steroidogenesis (calretinin, inhibin, steroidogenic factor 1),… read more here.
Keywords: ovarian tumors; hormone; epithelial ovarian; steroid hormone ... See more keywords
Papillary thyroid carcinoma with prominent myofibroblastic stromal component: clinicopathologic, immunohistochemical and next-generation sequencing study of seven cases
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0539-7
Abstract: Papillary thyroid carcinoma with desmoid-type fibromatosis or nodular fasciitis-like stroma is an extremely unusual and poorly understood subtype of papillary thyroid cancer. Although prior studies have demonstrated alterations in the Wnt/β-catenin signaling pathway in some… read more here.
Keywords: component; papillary thyroid; stroma; thyroid carcinoma ... See more keywords