A Novel Synthetic, Xeno‐Free Biomimetic Surface for Serum‐Free Expansion of Human Mesenchymal Stromal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000008
Abstract: Human mesenchymal stromal cells (hMSCs) have enormous potential for the treatment of various inflammatory and degenerative diseases. Their manufacturing for cell‐based therapies requires extensive ex vivo expansion and optimal growth conditions. To support cell adhesion,… read more here.
Keywords: human mesenchymal; mesenchymal stromal; expansion; stromal cells ... See more keywords
Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced functional materials"
DOI: 10.1002/adfm.201910442
Abstract: Engineered tissue models comprise a variety of multiplexed ensembles in which combinations of epithelial, stromal, and immune cells give rise to physiologic function. Engineering spatiotemporal control of cell-cell and cell-matrix interactions within these 3D multicellular… read more here.
Keywords: apoptosis stromal; apoptosis; stromal cells; cells engineer ... See more keywords
Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105811
Abstract: Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM) microenvironment, which have been widely implicated in pathways that contribute to leukemia growth and resistance. Recent reports showed genotypic and phenotypic alterations in… read more here.
Keywords: myeloid leukemia; mesenchymal stromal; leukemia; acute myeloid ... See more keywords
Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis
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DOI: 10.1002/advs.202504922
Abstract: Mesenchymal stromal cells (MSC) have emerged as a promising therapeutic option for neuropathic pain (NP), but the mechanisms remain elusive. Using murine pain models, it is demonstrated that MSC effectively alleviates pain, with efficacy comparable… read more here.
Keywords: npy2r sensory; brain; lung brain; mesenchymal stromal ... See more keywords
Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips (Adv. Sci. 14/2025)
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DOI: 10.1002/advs.202570093
Abstract: Pericytes Support Angiogenic Sprouting The image shows a blood vessel (red and green) sprouting between the columns of a microfluidic chip (blue) and invading the hydrogel above. This mechanism of vascularization is known as angiogenesis,… read more here.
Keywords: pericytes promote; vascularization stromal; stromal cells; promote vascularization ... See more keywords
Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000389
Abstract: Strategies aiming at increasing the survival and paracrine activity of human mesenchymal stromal cells (MSCs) are of utmost importance to achieve the full therapeutic potential of these cells. Herein, we propose both physical and biochemical… read more here.
Keywords: human mesenchymal; mesenchymal stromal; cells cultured; small molecule ... See more keywords
Umbilical cord derived mesenchymal stromal cells in microcarrier based industrial scale culture sustain the immune regulatory functions
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000558
Abstract: Mesenchymal stromal cells (MSCs) have been isolated from numerous sources and are potentially therapeutic against various diseases. Umbilical cord‐derived MSCs (UC‐MSCs) are considered superior to other tissue‐derived MSCs since they have a higher proliferation rate… read more here.
Keywords: mesenchymal stromal; stromal cells; microcarrier based; mscs ... See more keywords
Human adipose mesenchymal stromal cells growing into PCL‐nHA electrospun scaffolds undergo hypoxia adaptive ultrastructural changes
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology Journal"
DOI: 10.1002/biot.202200413
Abstract: Human Adipose‐Derived Mesenchymal Stem/Stromal Cells (hAD‐MSCs) have great potential for tissue regeneration. Since transplanted hAD‐MSCs are likely to be placed in a hypoxic environment, culturing the cells under hypoxic conditions might improve their post‐transplantation survival… read more here.
Keywords: hypoxic environment; nha nanofibers; human adipose; pcl nha ... See more keywords
Identification of critical process parameters for expansion of clinical grade human Wharton's jelly‐derived mesenchymal stromal cells in stirred‐tank bioreactors
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DOI: 10.1002/biot.202300381
Abstract: Cell therapies based on multipotent mesenchymal stromal cells (MSCs) are traditionally produced using 2D culture systems and platelet lysate‐ or serum‐containing media (SCM). Although cost‐effective for single‐dose autologous treatments, this approach is not suitable for… read more here.
Keywords: tank bioreactors; mesenchymal stromal; stromal cells; critical process ... See more keywords
PRESERVATION OF CRITICAL QUALITY ATTRIBUTES OF MESENCHYMAL STROMAL CELLS IN 3D BIOPRINTED STRUCTURES BY USING NATURAL HYDROGEL SCAFFOLDS.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28381
Abstract: 3D bioprinting is an emerging technology that enables complex spatial modelling of cell-based tissue engineering products, whose therapeutic potential in regenerative medicine is enormous. However, its success largely depends on the definition of a bioprintable… read more here.
Keywords: quality attributes; mesenchymal stromal; using natural; natural hydrogel ... See more keywords
Expansion of adipose tissue‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescence
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3267
Abstract: Multipotent mesenchymal stromal cells are considered as a perspective tool in cell therapy and regenerative medicine. Unfortunately, autologous cell therapy does not always provide positive outcomes in elder donors, perhaps as a result of the… read more here.
Keywords: replicative senescence; stromal cells; senescence; adipose tissue ... See more keywords