Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-α
Sign Up to like & getrecommendations! Published in 2017 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-017-1597-x
Abstract: Bmal1, a clock gene, is associated with depression, hypertrophy, metabolic syndrome and diabetes. Smad3, which is involved in the TGF-β signaling pathway, plays an important role in the regulation of tumor progression, fibrosis, obesity and… read more here.
Keywords: smad3 bmal1; bmal1; p21 s100a4; expression ... See more keywords
Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2019.12.001
Abstract: Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and… read more here.
Keywords: single cell; fibroblasts microenvironment; stromal fibroblasts; cancer ... See more keywords
The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-019-0100-7
Abstract: Abstractβ-catenin is a multifunctional protein that plays crucial roles in embryonic development, physiological homeostasis, and a wide variety of human cancers. Previously, we showed that in vivo targeted ablation of β-catenin in melanoma-associated fibroblasts after… read more here.
Keywords: catenin; melanoma associated; associated fibroblasts; stromal fibroblasts ... See more keywords
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0527-7
Abstract: Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy responses 1 . The inflammatory environment within tumours also influences responses to many therapies, including the efficacy of oncolytic viruses 2 ; however, the role… read more here.
Keywords: therapy; sting irf3; oncolytic viral; cancer cells ... See more keywords
Stromal fibroblasts from perimenopausal endometrium exhibit a different transcriptome than those from the premenopausal endometrium†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1093/biolre/iox092
Abstract: Abstract Human endometrium undergoes extensive regeneration on a cyclic basis in premenopausal women and likely occurs through the contribution of stem/progenitor cells. Menopause results in the permanent cessation of menstrual cycles and is preceded by… read more here.
Keywords: analysis; premenopausal; endometrium; biology ... See more keywords
Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00359-18
Abstract: Aging and stress promote senescence, which has intrinsic tumor suppressor functions and extrinsic tumor promoting properties. Therefore, it is of utmost importance to delineate the effects of senescence inducers on the various types of cells… read more here.
Keywords: senescent breast; luminal cells; senescence; breast luminal ... See more keywords
Sphingosine kinase 2 in stromal fibroblasts creates a hospitable tumor microenvironment in breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1638
Abstract: Reciprocal interactions between breast cancer cells and the tumor microenvironment are important for cancer progression and metastasis. We report here that the deletion or inhibition of sphingosine kinase 2 (SphK2), which produces sphingosine-1-phosphate (S1P), markedly… read more here.
Keywords: stromal fibroblasts; tumor microenvironment; breast cancer; tumor ... See more keywords
Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0927
Abstract: Ovarian cancer is a devastating disease due to its high incidence of relapse and chemoresistance. The tumor microenvironment, especially the tumor stroma compartment, was proven to contribute tremendously to the unsatisfactory chemotherapeutic efficacy in ovarian… read more here.
Keywords: ovarian cancer; cancer; stromal fibroblasts; progression ... See more keywords
Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells
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DOI: 10.1371/journal.ppat.1006163
Abstract: Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV… read more here.
Keywords: hiv infection; cd4 cells; infection; stromal fibroblasts ... See more keywords
Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13081987
Abstract: Simple Summary Ionizing radiation (a typical remedy for breast cancer) results in the premature senescence of the adjacent to the neoplastic cells stromal fibroblasts. Here, we showed that these senescent fibroblasts are characterized by the… read more here.
Keywords: breast; ionizing radiation; stromal fibroblasts; decorin ... See more keywords