Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment.
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DOI: 10.1053/j.gastro.2022.02.024
Abstract: BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma, which contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role… read more here.
Keywords: tumor; cancer; stromal hif2; microenvironment ... See more keywords