Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1).
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.014
Abstract: Epithelial-stromal interaction 1 (EPSTI1) was first discovered as a gene induced in breast cancer epithelial cells by co-cultured stromal fibroblasts. There are many reports on the role of Epsti1 in cancer malignancy. Epsti1 is now… read more here.
Keywords: epithelial stromal; role epsti1; role; interaction epsti1 ... See more keywords
Does stromal interaction molecule-1 have five senses?
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.12.001
Abstract: A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Recent work by Gudlur et… read more here.
Keywords: molecule five; five senses; interaction molecule; stromal interaction ... See more keywords
CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318015
Abstract: Background: Altered intracellular Ca2+ homeostasis in neonatal platelets has been previously reported. This study aims to examine the changes in the Ca2+ entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets. Methods: Human… read more here.
Keywords: capn1; stromal interaction; ca2; neonatal platelets ... See more keywords
Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model
Sign Up to like & getrecommendations! Published in 2020 at "BMC Gastroenterology"
DOI: 10.1186/s12876-020-01556-w
Abstract: Background Stromal fibroblasts associated with pancreatic ductal adenocarcinoma (PDAC) play an important role in tumor progression through interactions with cancer cells. Our proposed combination strategies of in vitro and in silico biomarker screening through a… read more here.
Keywords: cancer stromal; interaction model; biomarker; biomarker screening ... See more keywords
Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15177
Abstract: Stromal interaction molecule 1 (STIM1) is a major regulator of store‐operated calcium entry in non‐excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STIM1 in… read more here.
Keywords: interaction molecule; ca2 dependent; heart; stromal interaction ... See more keywords
The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113316
Abstract: Stromal interaction molecule (STIM)-1 and -2 regulate agonist-induced and basal cytosolic calcium (Ca2+) levels after oligomerization and translocation to endoplasmic reticulum (ER)-plasma membrane (PM) junctions. At these junctions, the STIM cytosolic coiled-coil (CC) domains couple… read more here.
Keywords: coiled coil; coil domains; interaction molecule; stromal interaction ... See more keywords