Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
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DOI: 10.1371/journal.pone.0189051
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and become major contributors to… read more here.
Keywords: stromal p53; pancreatic stellate; activation; p53 activation ... See more keywords