Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis
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DOI: 10.1158/1078-0432.ccr-24-3780
Abstract: Abstract Purpose: Peritoneal metastases (PM) in colorectal cancer portend a poor prognosis. We sought to elucidate molecular features differentiating primary tumors (PT) from PMs and actionable targets facilitating transcoelomic dissemination and progression. Experimental Design: We… read more here.
Keywords: colorectal cancer; cancer; spatial heterogeneity; stromal phenotypes ... See more keywords
Abstract 4912: Unsupervised detection of stromal phenotypes with distinct fibrogenic and inflamed properties in NSCLC
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DOI: 10.1158/1538-7445.am2024-4912
Abstract: Background: Understanding the composition of cancer-associated stroma (CAS) is vital, as the number and location of immune cells and fibroblasts, as well as the degree of extracellular matrix deposition, have implications for cancer progression and… read more here.
Keywords: cancer; stromal phenotypes; collagen; stroma ... See more keywords