Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.
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DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.
Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords
Diagnosing gastrointestinal stromal tumors: The utility of fine‐needle aspiration cytology versus biopsy
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DOI: 10.1002/cam4.4630
Abstract: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors in the intestinal tract originating from a precursor to the interstitial cells of Cajal, which plays a role in gastric motility. The preoperative diagnosis of GIST may be… read more here.
Keywords: diagnosing gastrointestinal; stromal tumors; utility fine; tumors utility ... See more keywords
Efficacy and safety of endoscopic “calabash” ligation and resection for small gastric stromal tumors originating from the muscularis propria
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DOI: 10.1002/cam4.5471
Abstract: We compared endoscopic “calabash” ligation and resection (ECLR) and endoscopic submucosal excision (ESE) in treating endophytic gastric stromal tumors (GSTs) ≤15 mm in diameter originating from the muscularis propria. read more here.
Keywords: calabash ligation; stromal tumors; gastric stromal; ligation resection ... See more keywords
Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ?
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DOI: 10.1002/jso.24514
Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Previous literature has suggested that small intestine GISTs are more aggressive than gastric GISTs. Our primary objective was to compare the… read more here.
Keywords: gastric small; intestine gastrointestinal; tumors outcomes; gastrointestinal stromal ... See more keywords
Elevated preoperative controlling nutritional status (CONUT) scores as a predictor of postoperative recurrence in gastrointestinal stromal tumors
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DOI: 10.1002/jso.27042
Abstract: The controlling nutritional status (CONUT) score is associated with the postoperative outcomes in various types of tumors, and its prognostic role in gastrointestinal stromal tumors (GISTs) needs to be clarified. read more here.
Keywords: nutritional status; stromal tumors; status conut; controlling nutritional ... See more keywords
Gastrointestinal stromal tumors (GIST): a proposal of a “CT-based predictive model of Miettinen index” in predicting the risk of malignancy
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DOI: 10.1007/s00261-019-02209-7
Abstract: To identify the predictors of malignancy on CT for the evaluation of gastrointestinal stromal tumors (GIST) by correlating CT findings with the mitotic index in order to propose a “CT-based predictive model of Miettinen index.”… read more here.
Keywords: index; radiology; gastrointestinal stromal; stromal tumors ... See more keywords
Comprehensive review of imaging features of sex cord-stromal tumors of the ovary
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DOI: 10.1007/s00261-021-02998-w
Abstract: Sex cord-stromal tumors of the ovary (SCST) are uncommon ovarian tumors arising from sex cord and/or stromal cells of the ovaries. They may be nonfunctional and asymptomatic or functional presenting with hyperestrogenic, hyperandrogenic or cushingoid… read more here.
Keywords: stromal tumors; sex cord; tumors ovary; cord stromal ... See more keywords
Gastric sub-epithelial tumors: identification of gastrointestinal stromal tumors using CT with a practical scoring method
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DOI: 10.1007/s10120-018-00908-6
Abstract: ObjectivesTo determine CT features that can identify gastrointestinal stromal tumors (GISTs) among gastric sub-epithelial tumors (SETs) and to explore a practical scoring method.MethodsSixty-four patients with gastric SETs (51 GISTs and 13 non-GISTs) from hospital I… read more here.
Keywords: non gists; scoring method; method; gastrointestinal stromal ... See more keywords
Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
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DOI: 10.1007/s10555-019-09818-0
Abstract: Gastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors molecularly matched to oncogenic KIT and PDGFRA mutations, GISTs have become a quintessential model for precision oncology.… read more here.
Keywords: sdh deficient; gastrointestinal stromal; stromal tumors; biology ... See more keywords
Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews
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DOI: 10.1007/s12029-019-00324-8
Abstract: Little is known about the sporadic coincidence of gastrointestinal stromal tumors (GISTs) with second primary tumors (SPTs). The aim of this study is to clarify if there is a clinicopathologic correlation responsible for the synchronous… read more here.
Keywords: gist patients; gastrointestinal stromal; stromal tumors; systematic reviews ... See more keywords
Resistance in gastrointestinal stromal tumors
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DOI: 10.1007/s12254-019-0486-5
Abstract: SummaryThe approval of imatinib for the treatment of patients with gastrointestinal stromal tumor has (GIST) revolutionized the treatment in the adjuvant setting and metastatic disease. Imatinib is an inhibitor of the receptor tyrosine kinases KIT… read more here.
Keywords: treatment; gastrointestinal stromal; stromal tumors; resistance gastrointestinal ... See more keywords