Emergence of SARS-CoV-2 through recombination and strong purifying selection
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DOI: 10.1126/sciadv.abb9153
Abstract: Frequent recombination and strong purifying selection facilitate the cross-species transmission of coronaviruses to humans. COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring… read more here.
Keywords: sars cov; recombination; strong purifying; purifying selection ... See more keywords
The Effect of Strong Purifying Selection on Genetic Diversity
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DOI: 10.1534/genetics.118.301058
Abstract: Negative selection is a ubiquitous evolutionary force, but its effects on diversity in large samples are poorly understood. Cvijović, Good, and Desai obtain simple analytical expressions for the whole population site frequency spectrum.... Purifying selection… read more here.
Keywords: diversity; genetic diversity; frequency; selection ... See more keywords