Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-05181-6
Abstract: Introduction In May 2013 and March 2014, the European Medicines Agency (EMA) issued two decisions restricting the use of strontium ranelate (SR). These risk minimisation measures (RMM) introduced new contraindications and limited the indications of… read more here.
Keywords: use strontium; minimisation measures; strontium ranelate; impact ... See more keywords
Effect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats
Sign Up to like & getrecommendations! Published in 2017 at "Calcified Tissue International"
DOI: 10.1007/s00223-017-0374-0
Abstract: Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In this study, the effect of different SR treatments on muscle was studied. Additionally, the… read more here.
Keywords: muscle; strontium ranelate; group; effect ... See more keywords
Morphological and immunohistochemical features of tooth extraction sites in rats treated with alendronate, raloxifene, or strontium ranelate.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical oral investigations"
DOI: 10.1007/s00784-020-03585-x
Abstract: OBJECTIVE The aim of this study was to evaluate morphological and immunohistochemical features of tooth extraction sites in rats subjected to different antiresorptive drugs. MATERIALS AND METHODS Wistar rats were allocated into 4 groups according… read more here.
Keywords: extraction; extraction sites; strontium ranelate; bone ... See more keywords
Chondroprotective effect of melatonin and strontium ranelate in animal model of osteoarthritis
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06760
Abstract: Purpose To analyze the action of strontium ranelate (SR) and melatonin in isolation or in association in knees, liver and kidneys of rats Wistar with induced osteoarthritis (OA). Methods Thirty male rats were induced to… read more here.
Keywords: chondroprotective effect; strontium ranelate; association; liver kidneys ... See more keywords
Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.02.793
Abstract: OBJECTIVE To investigate the effects of different strontium ranelate (SrR) doses alone or in combination with low-intensity and high-frequency mechanical vibration (MV) on articular cartilage in ovariectomized rats. DESIGN Fifty 6-month-old female Wistar rats underwent… read more here.
Keywords: ovariectomized rats; mechanical vibration; vibration; strontium ranelate ... See more keywords
Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants
Sign Up to like & getrecommendations! Published in 2018 at "Transactions of Nonferrous Metals Society of China"
DOI: 10.1016/s1003-6326(18)64820-4
Abstract: Abstract Titanium and its alloys are commonly used as dental and bone implant materials. Biomimetic coating of titanium surfaces could improve their osteoinductive properties. In this work, we have developed a novel osteogenic composite nanocoating… read more here.
Keywords: composite nanocoating; strontium ranelate; bone; osteogenic composite ... See more keywords
The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20203003
Abstract: Abstract Aseptic loosening following periprosthetic osteolysis is the primary complication that limits the lifetime of total joint arthroplasty (TJA). The wear particles trigger a chronic inflammation response in the periprosthetic tissue and turn over the… read more here.
Keywords: periprosthetic osteolysis; strontium ranelate; ranelate; particle induced ... See more keywords
Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20187440
Abstract: Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA… read more here.
Keywords: strontium ranelate; systematic review; disease modifying; disease ... See more keywords
Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Bioengineering"
DOI: 10.3390/bioengineering10030365
Abstract: Strontium ranelate (SR) is a pharmaceutical agent used for the prevention and treatment of osteoporosis and fragility fracture. However, little attention has been paid to the effect of SR on alveolar bone remodeling during orthodontic… read more here.
Keywords: strontium ranelate; orthodontic tooth; osteoclastogenesis pathway; tooth movement ... See more keywords
EFFECTS OF STRONTIUM RANELATE ON ALVEOLAR BONE IN RATS WITH EXPERIMENTAL DIABETES MELLITUS.
Sign Up to like & getrecommendations! Published in 2022 at "Wiadomosci lekarskie"
DOI: 10.36740/wlek202201201
Abstract: OBJECTIVE The aim: To investigate effects of strontium ranelate on alveolar bone loss in rats with experimental diabetes. PATIENTS AND METHODS Materials and methods: Histological examination of bone tissue was carried out for 24 white… read more here.
Keywords: alveolar bone; bone; strontium ranelate; group ... See more keywords
Strontium ranelate reduces the progression of titanium particle-induced osteolysis by increasing the ratio of osteoprotegerin to receptor activator of nuclear factor-κB ligand in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8292
Abstract: The present study aimed to investigate the effects of strontium ranelate (SR), an anti‑osteoporotic drug, on osteolysis in an experimental mouse model of aseptic loosening. A total of 45 female C57BL/6J mice each received implantation… read more here.
Keywords: strontium ranelate; receptor activator; group; titanium ... See more keywords