Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2020.07.007
Abstract: Pharmacotherapeutics for treatment of psychostimulant use disorder are still an unmet medical goal. Recently, off label use of modafinil (MOD), an approved medication for treatment of sleep disturbances, has been tested as a therapeutic for… read more here.
Keywords: structural analogs; use; psychostimulant use; modafinil structural ... See more keywords
Investigation on the Anticancer Activity of [6]-Gingerol of Zingiber officinale and its Structural Analogs against Skin Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230418095105
Abstract: AIM Skin cancer is the most common type of cancer caused by the uncontrolled growth of abnormal cells in the epidermis and the outermost skin layer. INTRODUCTION This study aimed to study the anti-skin cancer… read more here.
Keywords: anticancer activity; skin cancer; gingerol; structural analogs ... See more keywords
Structural analogs of 2-(4-fluorophenyl)-6-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine for targeting Candida albicans non-essential stress kinase Yck2 through protein-ligand binding and dynamics analysis
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2024.1430157
Abstract: The rise in drug-resistant fungal infections poses a significant public health concern, necessitating the development of new antifungal therapies. We aimed to address this challenge by targeting a yeast casein kinase of Candida albicans for… read more here.
Keywords: yck2; candida albicans; structural analogs; fluorophenyl methyl ... See more keywords
Recent Advances in Sources, Migration, Public Health, and Surveillance of Bisphenol A and Its Structural Analogs in Canned Foods
Sign Up to like & getrecommendations! Published in 2023 at "Foods"
DOI: 10.3390/foods12101989
Abstract: The occurrence of bisphenol A (BPA) and its structural analogs, known as endocrine disruptors is widely reported. Consumers could be exposed to these chemicals through canned foods, leading to health risks. Considerable advances have occurred… read more here.
Keywords: health; canned foods; health surveillance; bisphenol ... See more keywords
Quercetin and Its Structural Analogs as NUDT5 Inhibitors: A Preliminary In Silico Study
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26188843
Abstract: Nucleotide diphosphate hydrolase type 5 (NUDT5) plays a significant role in the estrogen-signaling pathway and is overexpressed in breast cancer. This study aimed to explore the anti-breast cancer potential of quercetin and its 52 structural… read more here.
Keywords: breast cancer; structural analogs; gbsa calculations; quercetin structural ... See more keywords
The Legacy of AAZTA—Synthesis and Coordination Chemistry of Two AAZTA Structural Analogs
Sign Up to like & getrecommendations! Published in 2024 at "Inorganics"
DOI: 10.3390/inorganics12090235
Abstract: AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) is a mesocyclic chelating agent forming stable complexes with several metal ions. Over the past 20 years since its inception, AAZTA and its bifunctional derivatives have gained a growing role in several… read more here.
Keywords: legacy aazta; chemistry; aazta synthesis; structural analogs ... See more keywords
Time-Course Metabolomic Analysis: Production of Betaine Structural Analogs by Fungal Fermentation of Seaweed
Sign Up to like & getrecommendations! Published in 2024 at "Metabolites"
DOI: 10.3390/metabo14040201
Abstract: Betaine structural analogs are compounds characterized by the presence of positive and negative charges in a single molecule and have been reported to have physiological properties, such as anti-inflammatory activities. In this study, we performed… read more here.
Keywords: betaine structural; metabolomic analysis; structural analogs; fermentation ... See more keywords
Natural Polyphenols Inhibit the Dimerization of the SARS-CoV-2 Main Protease: The Case of Fortunellin and Its Structural Analogs
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26196068
Abstract: 3CL-Pro is the SARS-CoV-2 main protease (MPro). It acts as a homodimer to cleave the large polyprotein 1ab transcript into proteins that are necessary for viral growth and replication. 3CL-Pro has been one of the… read more here.
Keywords: structural analogs; dimerization; cov main; main protease ... See more keywords