Structural Basis of Nucleosome Recognition and Modulation
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.201900234
Abstract: Chromatin structure and dynamics regulate key cellular processes such as DNA replication, transcription, repair, remodeling, and gene expression, wherein different protein factors interact with the nucleosomes. In these events, DNA and RNA polymerases, chromatin remodeling… read more here.
Keywords: structural basis; basis nucleosome; dna; nucleosome recognition ... See more keywords
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200052
Abstract: Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of… read more here.
Keywords: endoplasmic reticulum; functional regulation; structural basis; reticulum ... See more keywords
Structural basis of BMP‐2 and BMP‐7 interactions with antagonists Gremlin‐1 and Noggin in Glioblastoma tumors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26407
Abstract: In Glioblastoma (GBM) brain tumors, both Gremlin‐1 and Noggin are reported to bind to BMP and inhibit BMP‐signaling, thereby allowing the cell to maintain tumorous morphology. Enlisting the interfacial residues important for protein–protein complex formation… read more here.
Keywords: structural basis; bmp; gremlin noggin; glioblastoma ... See more keywords
Structural basis of generic versus specific E2–RING E3 interactions in protein ubiquitination
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3690
Abstract: Protein ubiquitination is a fundamental regulatory component in eukaryotic cell biology, where a cascade of ubiquitin activating (E1), conjugating (E2), and ligating (E3) enzymes assemble distinct ubiquitin signals on target proteins. E2s specify the type… read more here.
Keywords: structural basis; basis generic; generic versus; protein ubiquitination ... See more keywords
Structural Basis for Signaling Through Shared Common γ Chain Cytokines.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_1
Abstract: The common γ chain (γc) family of hematopoietic cytokines consists of six distinct four α-helix bundle soluble ligands that signal through receptors which include the shared γc subunit to coordinate a wide range of physiological… read more here.
Keywords: common chain; structural basis; cytokine; family ... See more keywords
Structural basis of homologous recombination
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03365-1
Abstract: Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein filament on ssDNA, pairs with homologous DNA as… read more here.
Keywords: structural basis; dna; microscopy; homologous recombination ... See more keywords
The structural basis for membrane assembly of immunoreceptor signalling complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4165-6
Abstract: Immunoreceptors are TM complexes that consist of separate ligand-binding and signal-transducing modules. Mounting evidence suggests that interactions with the local environment may influence the architecture of these TM domains, which assemble via crucial sets of… read more here.
Keywords: structural basis; membrane assembly; basis membrane; immunoreceptor ... See more keywords
Structural basis for the interaction between DJ-1 and Bcl-XL.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.129
Abstract: DJ-1 is a multifunctional protein associated with Parkinson's disease (PD) and tumorigenesis. In response to ultraviolet B (UVB) irradiation, DJ-1 is translocated into the mitochondria, and its interaction with the mitochondrial protein Bcl-XL protects cells… read more here.
Keywords: structural basis; interaction bcl; basis interaction; interaction ... See more keywords
Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.093
Abstract: The human mitochondrial alpha-ketoglutarate (α-KG) dehydrogenase complex (hKGDHc) is a well-studied macromolecular enzyme that converts α-KG to succinyl-CoA and NADH. Abnormalities of the complex lead to several diseases, including neurodegenerative disorders. Despite its importance in… read more here.
Keywords: regulation human; activity regulation; structural basis; dehydrogenase ... See more keywords
Structural basis for the catalytic activities of the multifunctional enzyme quinolinate synthase
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DOI: 10.1016/j.ccr.2020.213370
Abstract: Abstract The [4Fe-4S]-containing enzyme quinolinate synthase, also called NadA, catalyzes the synthesis of quinolinic acid (QA) using what is probably the oldest pathway to generate this universal precursor of the biological cofactor nicotinamide dinucleotide (NAD).… read more here.
Keywords: basis catalytic; enzyme quinolinate; structural basis; quinolinate synthase ... See more keywords
Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.12.005
Abstract: Key metabolites act through specific G protein-coupled receptors (GPCRs) as extracellular signals of fuel availability and metabolic stress. Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for… read more here.
Keywords: structural basis; basis gpcr; signaling small; small polar ... See more keywords