Biointerface Coatings With Structural and Biochemical Properties Modifications of Biomaterials
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202202286
Abstract: Designing a successful biological interface for a biomaterial requires the application of concepts from multiple fields, including materials science, surface science, nanoscience, physics, and biochemistry. With current biomaterials, such as polymers, ceramics, and natural materials,… read more here.
Keywords: biointerface coatings; coatings structural; properties modifications; biochemical properties ... See more keywords
Structural and biochemical modifications of model and native membranes of human immune cells in response to the action of zinc oxide nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4057
Abstract: The development of nanotechnology has led to the increased production of zinc oxide nanoparticles (ZnO‐NPs) and their application in a wide variety of everyday products. It creates the need for a full assessment of their… read more here.
Keywords: structural biochemical; zno nps; zinc; oxide nanoparticles ... See more keywords
Structural and biochemical insights into FKBP51 as a Hsp90 co-chaperone.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30384
Abstract: The FK506-binding protein 51 (FKBP51) is a high-molecular-weight immunophilin that emerged as an important drug target for stress-related disorders, chronic pain, and obesity. It has been implicated in a plethora of molecular pathways but remains… read more here.
Keywords: fkbp51 hsp90; insights fkbp51; biochemical insights; chaperone ... See more keywords
Disaggregation of Aβ42 for Structural and Biochemical Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7811-3_20
Abstract: The amyloid-β (Aβ) peptides that form the amyloid fibrils associated with Alzheimer's disease are generated by sequential proteolysis of the amyloid precursor protein by β- and γ-secretase. The two predominant Aβ peptides, Aβ40 and Aβ42,… read more here.
Keywords: disaggregation structural; biochemical studies; biology; structural biochemical ... See more keywords
Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05942-7
Abstract: A family of DEDDh 3′→5′ exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3′ ends. Here, we report the crystal structure of Arabidopsis… read more here.
Keywords: small rna; end trimming; structural biochemical; arabidopsis sdn1 ... See more keywords
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03320-w
Abstract: Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)1–7. In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact… read more here.
Keywords: mechanisms nlrp1; structural biochemical; biochemical mechanisms; dpp9 ... See more keywords
Structural and Biochemical Characterization of Apicomplexan Inorganic Pyrophosphatases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05234-y
Abstract: Inorganic pyrophosphatases (PPase) participate in energy cycling and they are essential for growth and survival of organisms. Here we report extensive structural and functional characterization of soluble PPases from the human parasites Plasmodium falciparum (PfPPase)… read more here.
Keywords: characterization apicomplexan; structural biochemical; pfppase; biochemical characterization ... See more keywords
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20171666
Abstract: The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the ‘Warburg effect’. The activation and further metabolism of glucose is initiated by… read more here.
Keywords: structural biochemical; human hexokinase; conformation; half ... See more keywords
Structural and biochemical insights into Zn2+-bound EF-hand proteins, EFhd1 and EFhd2
Sign Up to like & getrecommendations! Published in 2023 at "IUCrJ"
DOI: 10.1107/s2052252523001501
Abstract: The EF-hands within the crystal structures of the Zn2+-bound EFhd1 and EFhd2 core domains coordinate Zn2+ ions. EFhd1 and EFhd2 exhibited Ca2+- and Zn2+-independent actin binding and Ca2+- and Zn2+-dependent actin-bundling activity, and these suggest… read more here.
Keywords: ca2 zn2; biochemical insights; zn2 bound; structural biochemical ... See more keywords
Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01095-22
Abstract: OXA-48-producing Enterobacterales have now widely disseminated throughout the world. Several variants have now been reported, differing by just a few amino-acid substitutions or deletions, mostly in the region of the loop β5-β6. ABSTRACT OXA-48-producing Enterobacterales… read more here.
Keywords: oxa 517; expanded spectrum; spectrum cephalosporin; structural biochemical ... See more keywords
Aging-Induced Biological Changes and Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/7156435
Abstract: Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are… read more here.
Keywords: induced biological; aging induced; structural biochemical; cardiovascular diseases ... See more keywords