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   Articles with "structural bioinformatics" as a keyword



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Structural bioinformatics analysis of variants on GPCR function.

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recommendations! Published in 2019 at "Current opinion in structural biology"

DOI: 10.1016/j.sbi.2019.04.007

Abstract: G protein-coupled receptors (GPCRs) are key membrane-embedded receptor proteins, with critical roles in cellular signal transduction. In the era of precision medicine, understanding the role of natural variants on GPCR function is critical, especially from… read more here.

Keywords: medicine; gpcr function; variants gpcr; analysis variants ... See more keywords

A structural bioinformatics investigation on protein-DNA complexes delineates their modes of interaction.

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recommendations! Published in 2017 at "Molecular bioSystems"

DOI: 10.1039/c7mb00071e

Abstract: The lifetimes of protein-DNA adducts are strictly related to the various protein functions. This feature must be encoded by the amino acids located at the protein-DNA interface. The large number of structurally characterized protein-DNA complexes… read more here.

Keywords: dna; protein dna; dna complexes; contact ... See more keywords

The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies

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recommendations! Published in 2021 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbaa362

Abstract: Abstract SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has posed a worldwide challenge to human health as no effective treatment is currently available to combat the disease. Its severity has… read more here.

Keywords: bioinformatics tools; tools resources; host; structure ... See more keywords
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BioCommons: a robust java library for RNA structural bioinformatics

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recommendations! Published in 2021 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btab069

Abstract: Abstract Motivation Biomolecular structures come in multiple representations and diverse data formats. Their incompatibility with the requirements of data analysis programs significantly hinders the analytics and the creation of new structure-oriented bioinformatic tools. Therefore, the… read more here.

Keywords: java library; bioinformatics biocommons; rna; robust java ... See more keywords
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The structural bioinformatics library: modeling in biomolecular science and beyond

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recommendations! Published in 2017 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btw752

Abstract: Motivation: Software in structural bioinformatics has mainly been application driven. To favor practitioners seeking off‐the‐shelf applications, but also developers seeking advanced building blocks to develop novel applications, we undertook the design of the Structural Bioinformatics… read more here.

Keywords: modeling biomolecular; library modeling; bioinformatics library; sbl ... See more keywords

Olfactory GPCRs through the lens of structural bioinformatics

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recommendations! Published in 2025 at "Chemical Senses"

DOI: 10.1093/chemse/bjaf038

Abstract: Abstract Olfactory perception, mediated by G protein-coupled receptors (GPCRs) such as odorant receptors (ORs) and trace amine-associated receptors (TAARs), plays a pivotal role in human health, influencing behaviors like food choices and serving as early… read more here.

Keywords: olfactory gpcrs; bioinformatics olfactory; structural bioinformatics; gpcrs lens ... See more keywords

Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae1235

Abstract: Abstract Dinucleases of the DEDD superfamily, such as oligoribonuclease, Rexo2 and nanoRNase C, catalyze the essential final step of RNA degradation, the conversion of di- to mononucleotides. The active sites of these enzymes are optimized… read more here.

Keywords: genomic islands; identify deoxydinucleotide; bioinformatics analyses; analyses identify ... See more keywords

Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0300340

Abstract: Monoamine transporters including transporters for serotonin, dopamine, and norepinephrine play key roles in monoaminergic synaptic signaling, involving in the molecular etiology of a wide range of neurological and physiological disorders. Despite being crucial drug targets,… read more here.

Keywords: bioinformatics studies; serotonin dopamine; dopamine norepinephrine; qty ... See more keywords