Structural bioinformatics analysis of variants on GPCR function.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.04.007
Abstract: G protein-coupled receptors (GPCRs) are key membrane-embedded receptor proteins, with critical roles in cellular signal transduction. In the era of precision medicine, understanding the role of natural variants on GPCR function is critical, especially from… read more here.
Keywords: medicine; gpcr function; variants gpcr; analysis variants ... See more keywords
A structural bioinformatics investigation on protein-DNA complexes delineates their modes of interaction.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00071e
Abstract: The lifetimes of protein-DNA adducts are strictly related to the various protein functions. This feature must be encoded by the amino acids located at the protein-DNA interface. The large number of structurally characterized protein-DNA complexes… read more here.
Keywords: dna; protein dna; dna complexes; contact ... See more keywords
The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaa362
Abstract: Abstract SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has posed a worldwide challenge to human health as no effective treatment is currently available to combat the disease. Its severity has… read more here.
Keywords: bioinformatics tools; tools resources; host; structure ... See more keywords
BioCommons: a robust java library for RNA structural bioinformatics
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab069
Abstract: Abstract Motivation Biomolecular structures come in multiple representations and diverse data formats. Their incompatibility with the requirements of data analysis programs significantly hinders the analytics and the creation of new structure-oriented bioinformatic tools. Therefore, the… read more here.
Keywords: java library; bioinformatics biocommons; rna; robust java ... See more keywords
The structural bioinformatics library: modeling in biomolecular science and beyond
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw752
Abstract: Motivation: Software in structural bioinformatics has mainly been application driven. To favor practitioners seeking off‐the‐shelf applications, but also developers seeking advanced building blocks to develop novel applications, we undertook the design of the Structural Bioinformatics… read more here.
Keywords: modeling biomolecular; library modeling; bioinformatics library; sbl ... See more keywords