Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114314
Abstract: Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in the drug discovery and development of anticancer agents. Despite having numerous biological effects, the most important activity reported for shikonin derivatives is the… read more here.
Keywords: advances antitumor; recent advances; structural classification; action ... See more keywords
Kincore: a web resource for structural classification of protein kinases and their inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab920
Abstract: The active form of kinases is shared across different family members, as are several commonly observed inactive forms. We previously performed a clustering of the conformation of the activation loop of all protein kinase structures… read more here.
Keywords: protein; kincore web; resource structural; web resource ... See more keywords
Recent advances of polyoxometalate-catalyzed selective oxidation based on structural classification.
Sign Up to like & getrecommendations! Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618010902
Abstract: The structural diversity and tenability observed in POMs has encouraged extensive investigations into their catalytic activity. Based on the structural classification of POMs, this review summarizes recent advances relating to POM-catalyzed selective oxidation and places… read more here.
Keywords: catalyzed selective; selective oxidation; recent advances; structural classification ... See more keywords