Disrupting the Systems: Opportunities to Enhance Methodological Approaches to Address Socio-Structural Determinants of HIV and End the Epidemic Through Effective Community Engagement
Sign Up to like & getrecommendations! Published in 2021 at "AIDS and Behavior"
DOI: 10.1007/s10461-021-03475-7
Abstract: A world without HIV is only possible by addressing the socio-structural determinants of health. Our understanding of socio-structural determinants is constantly changing, and parallel changes must occur with the methodologies used to explain the drivers… read more here.
Keywords: socio structural; community engagement; determinants hiv; structural determinants ... See more keywords
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.029
Abstract: BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential to… read more here.
Keywords: bax; pro apoptotic; membrane permeabilization; membrane ... See more keywords
Structural determinants of multimerization and dissociation in 2-Cys peroxiredoxin chaperone function.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.04.007
Abstract: Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently, they have been shown to also carry out additional roles as molecular chaperones. To address this emerging supplementary function, this review focuses on… read more here.
Keywords: multimerization dissociation; determinants multimerization; function; chaperone function ... See more keywords
Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.6b00813
Abstract: Heterotrimeric guanine nucleotide-binding proteins (Gα proteins) are intracellular nanomachines deputed to signal transduction. The switch-on process requires the release of bound GDP from a site at the interface between GTPase and helical domains. Nucleotide release… read more here.
Keywords: collective motions; nucleotide binding; determinants constitutive; constitutive activation ... See more keywords
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02163
Abstract: Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modulator imidazo[1,2-a]pyridine… read more here.
Keywords: ds2; acid type; type receptors; containing aminobutyric ... See more keywords
Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00352
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is one of the leading causes of death in developing countries. Non-tuberculous mycobacteria (NTM) infections are rising and prey upon patients with structural lung diseases such as chronic… read more here.
Keywords: carboxamides identification; lead acetamides; indole carboxamides; determinants indole ... See more keywords
Structural determinants of a permeation barrier of the SecYEG translocon in the active state
Sign Up to like & getrecommendations! Published in 2021 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d1cp02702f
Abstract: The SecYEG translocon is a channel in bacteria, which provides a passage for secretory proteins across as well as integration of membrane proteins into the plasma membrane. The molecular mechanism, by which SecYEG manages protein… read more here.
Keywords: structural determinants; translocon active; active state; secyeg translocon ... See more keywords
Structural determinants of dual incretin receptor agonism by tirzepatide
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116506119
Abstract: Significance Tirzepatide is a dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), which are incretin receptors that regulate carbohydrate metabolism. This investigational agent has proven superior to selective… read more here.
Keywords: tirzepatide; determinants dual; dual incretin; structural determinants ... See more keywords
Structural determinants of phytoremediation capacity in saltmarsh halophyte Diplachne fusca (L.) P. Beauv. ex Roem. & Schult. subsp. fusca
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Phytoremediation"
DOI: 10.1080/15226514.2022.2098251
Abstract: Abstract Micro and macro-morphological features contribute to plants’ tolerance to a variety of environmental pollutants. The contribution of such structural modifications in the phytoremediation potential of Diplachne fusca populations collected from five saline habitats were… read more here.
Keywords: structural determinants; fusca; diplachne fusca; determinants phytoremediation ... See more keywords
COVID-19 violence and the structural determinants of death: Canada’s seasonal agricultural worker programme
Sign Up to like & getrecommendations! Published in 2022 at "Global Public Health"
DOI: 10.1080/17441692.2022.2053735
Abstract: ABSTRACT The Seasonal Agricultural Worker Program (SAWP) is a managed migration programme that aims to fill labour shortages in Canada’s agricultural industry with Black and Brown workers from the global South. For decades, migrant workers,… read more here.
Keywords: violence; agricultural worker; death; determinants death ... See more keywords
Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of pharmacology"
DOI: 10.1111/bph.15267
Abstract: BACKGROUND The TRPV4 cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting pharmacological target with therapeutic potential. However, little is known about the… read more here.
Keywords: channel modulators; inhibition; channel; trpv4 ... See more keywords