Homology modeling in a dynamical world
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3274
Abstract: A key concept in template‐based modeling (TBM) is the high correlation between sequence and structural divergence, with the practical consequence that homologous proteins that are similar at the sequence level will also be similar at… read more here.
Keywords: structural divergence; diversity; correlation; conformational diversity ... See more keywords
How is structural divergence related to evolutionary information?
Sign Up to like & getrecommendations! Published in 2018 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2018.06.033
Abstract: The analysis of evolutionary information in a protein family, such as conservation and covariation, is often linked to its structural information. Multiple sequence alignments of distant homologous sequences are used to measure evolutionary variables. Although… read more here.
Keywords: structural information; information; structural divergence; evolutionary information ... See more keywords