Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans
Sign Up to like & getrecommendations! Published in 2018 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2018.11.020
Abstract: The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human… read more here.
Keywords: cytotoxic; synthesis structural; structural diversification; regioselective synthesis ... See more keywords
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00763
Abstract: The structural diversification of natural products is instrumental to their versatile bioactivities. In this context, redox tailoring enzymes are commonly involved in the modification and functionalization of advanced pathway intermediates en route to the mature… read more here.
Keywords: diversification natural; three rings; structural diversification; natural products ... See more keywords
Precursor Heterogeneity Driven Mo-Te Nanoparticle Structural Diversification for Cancer Photo-Theranostics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c20634
Abstract: Chemical reactions between homogeneous precursors are typically used to synthesize monodisperse nanoparticles with well-controlled size and morphology. It is difficult to predict the evolved nanostructures when using two heterogeneous precursors. In this study, three types… read more here.
Keywords: cancer; heterogeneity driven; nanoparticle structural; driven nanoparticle ... See more keywords
Redox- and metal-directed structural diversification in designed metalloprotein assemblies.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02440c
Abstract: Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through… read more here.
Keywords: redox metal; structural diversification; metal directed; directed structural ... See more keywords
The Diversity of Lipopeptides in the Pseudomonas syringae Complex Parallels Phylogeny and Sheds Light on Structural Diversification during Evolutionary History
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01456-22
Abstract: This study provides an insight into the P. syringae metabolome that emphasizes the high diversity of lipopeptides produced within the P. syringae complex. The production profiles of strains are closely related to their phylogenetic classification,… read more here.
Keywords: diversity lipopeptides; syringae complex; structural diversification; syringae ... See more keywords