Structural exploration of multifunctional monoamine oxidase B inhibitors as potential drug candidates against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105070
Abstract: AD is one of the most typical neurodegenerative disorders that suffer many seniors worldwide. Recently, MAO inhibitors have received increasing attention not only for their roles involved in monoamine neurotransmitters metabolism and oxidative stress but… read more here.
Keywords: structural exploration; exploration multifunctional; monoamine oxidase; mao inhibitors ... See more keywords
Structural exploration of arylsulfonamide-based ADAM17 inhibitors through validated comparative multi-QSAR modelling studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.02.081
Abstract: Abstract Zinc-dependent ADAM17 takes part in a number of life-threatening conditions such as inflammatory diseases, cancer, Alzheimer's disease and rheumatoid arthritis. Therefore, ADAM17 may be a valuable target to design specific inhibitors for combating these… read more here.
Keywords: inhibitors validated; adam17 inhibitors; exploration arylsulfonamide; based adam17 ... See more keywords
Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2024254
Abstract: Abstract Histone deacetylase (HDAC) inhibitors, are new class of cancer chemotherapeutics used in clinical development. It plays a pivotal role in restoring the acetylation balance and lysine residual deacetylation in histone and non-histone proteins. Notably,… read more here.
Keywords: structural exploration; pharmacophore based; histone; berberine derivatives ... See more keywords
Structural Exploration on Palmitoyltransferase DHHC3 from Homo sapiens
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14153013
Abstract: DHHC3 belongs to a family of DHHC palmitoyltransferase, which catalyzes the S-palmitoylation of target proteins by attaching a fatty acyl group to a cysteine. Recently, DHHC3 has been demonstrated to be a promising antitumor target… read more here.
Keywords: palmitoyltransferase dhhc3; structural exploration; dhhc3; exploration palmitoyltransferase ... See more keywords