Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00644
Abstract: We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68,… read more here.
Keywords: fine tuning; vivo adjuvant; adjuvant activity; structural fine ... See more keywords
Structural fine-tuning of zwitterionic salts for the discovery of LCST-type thermoresponsive materials
Sign Up to like & getrecommendations! Published in 2021 at "Materials Chemistry Frontiers"
DOI: 10.1039/d1qm01018b
Abstract: In our current work, we discovered N-triflimide (NTf)-based zwitterionic ionic liquids (ZILs) exhibiting LCST phase transitions in water and showed an ability to further fine tune their structure to afford N-pentafluoroethylsulfonimide (NPf)-based ZILs displaying Tc… read more here.
Keywords: fine tuning; zwitterionic salts; tuning zwitterionic; structural fine ... See more keywords