Structural Insight into H‐NOX Gas Sensing and Cognate Signaling Protein Regulation
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800478
Abstract: Heme‐nitric oxide/oxygen binding (H‐NOX) proteins are a family of gas‐binding hemoproteins that bind diatomic gas ligands such as nitric oxide (NO) and oxygen (O2). In bacteria, H‐NOXs are often associated with signaling partners, including histidine… read more here.
Keywords: structural insight; gas; cognate signaling; insight nox ... See more keywords
Cryptochromes: Photochemical and structural insight into magnetoreception
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4124
Abstract: Cryptochromes (CRYs) function as blue light photoreceptors in diverse physiological processes in nearly all kingdoms of life. Over the past several decades, they have emerged as the most likely candidates for light‐dependent magnetoreception in animals,… read more here.
Keywords: insight magnetoreception; structural insight; cryptochromes photochemical; signal transduction ... See more keywords
Structural insight into the substrate specificity of PLP fold type IV transaminases
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10369-6
Abstract: Pyridoxal-5′-phosphate-dependent transaminases of fold type IV (class IV) are promising enzymes for ( R )-selective amination of organic compounds. Transaminases of fold type IV exhibit either strict ( R )-selectivity or ( S )-selectivity that… read more here.
Keywords: amino acid; structural insight; fold type; substrate specificity ... See more keywords
Structural Insight into a Membrane Intrinsic Acyltransferase from Chlorobium tepidum
Sign Up to like & getrecommendations! Published in 2019 at "Current Microbiology"
DOI: 10.1007/s00284-019-01743-3
Abstract: The Lipid A component of the outer membrane of Gram-negative bacteria is an integral part of the permeability barrier known as LPS, which actively prevents the uptake of bactericidal compounds. It is clinically very significant,… read more here.
Keywords: acyltransferase chlorobium; chlorobium tepidum; structural insight; membrane ... See more keywords
Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.002
Abstract: Vernalization is a pivotal stage for some plants involving many epigenetic changes during cold exposure. In Arabidopsis, an essential step in vernalization for further flowering is successful silence the potent floral repressor Flowering Locus C… read more here.
Keywords: structural insight; insight role; role val1; arabidopsis ... See more keywords
Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2016.09.020
Abstract: The plant homeodomain (PHD) finger of Set3 binds methylated lysine 4 of histone H3 in vitro and in vivo; however, precise selectivity of this domain has not been fully characterized. Here, we explore the determinants… read more here.
Keywords: insight recognition; structural insight; phd; phd finger ... See more keywords
Structural Insight into BLM Recognition by TopBP1.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.08.005
Abstract: Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through either… read more here.
Keywords: structural insight; blm recognition; brct5; recognition topbp1 ... See more keywords
A structural insight of bedaquiline for the cardiotoxicity and hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.06.005
Abstract: Bedaquiline was approved by USFDA in 2012 for pulmonary MDR-TB. The IC50 value of bedaquiline was reported to be remarkably low (25 nM), effectively inhibiting mycobacterial ATP synthase. In addition to these obvious assets of bedaquiline,… read more here.
Keywords: insight bedaquiline; structural insight; cardiotoxicity hepatotoxicity; bedaquiline ... See more keywords
Structural Insight into Aggregation and Orientation of TPD-Based Conjugated Polymers for Efficient Charge-Transporting Properties
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.8b04605
Abstract: In this study, we obtained a new structural insight into the charge-transporting properties in TPD-based polymers that cannot be solely explained in terms of the type of orientation. We synthesized... read more here.
Keywords: orientation; transporting properties; structural insight; charge transporting ... See more keywords
Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00316
Abstract: Staphylococcus aureus Stp1, which belongs to the bacterial metal-dependent protein phosphatase (PPM) family, is a promising candidate for antivirulence targeting. How Stp1 recognizes the phosphorylated peptide remains unclear, however. In order to investigate the recognition… read more here.
Keywords: staphylococcus aureus; structural insight; mechanism; aureus stp1 ... See more keywords
Structural insight into the assembly and conformational activation of human origin recognition complex
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-00232-3
Abstract: The function of the origin recognition complex (ORC) in DNA replication is highly conserved in recognizing and marking the initiation sites. The detailed molecular mechanisms by which human ORC is reconfigured into a state competent… read more here.
Keywords: structural insight; assembly conformational; origin recognition; insight assembly ... See more keywords