Biochemical and structural insights into an allelic variant causing the lysosomal storage disorder – aspartylglucosaminuria
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13190
Abstract: Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by defects of the hydrolase glycosylasparaginase (GA). Previously, we showed that a Canadian AGU mutation disrupts an obligatory intramolecular autoprocessing with the enzyme trapped as an inactive… read more here.
Keywords: lysosomal storage; storage disorder; biochemical structural; structural insights ... See more keywords
Structural insights into anticancer activity of D-ring modified estrone derivatives using their lipophilicity in estimation of SAR and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2242
Abstract: Many forms of breast carcinoma are hormone-dependent and therefore development of novel aromatase inhibitors is of particular interest. Since brain metastases are frequent in patients with advanced breast carcinoma, one of the goals of modern… read more here.
Keywords: docking studies; analysis; lipophilicity; structural insights ... See more keywords
Structural Insights into the Hydrogen-Bonding and Folding Pattern in Ant-Ant-Pro-Gly Tetrapeptides
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700181
Abstract: In this paper, we provide structural insights into the hydrogen-bonding and folding pattern in Ant-Ant-Pro-Gly tetrapeptides (Ant: anthranilic acid; Pro: proline; and Gly: glycine). Comparison of the C-terminal esters and their amide analogs revealed strikingly… read more here.
Keywords: folding pattern; insights hydrogen; structural insights; bonding folding ... See more keywords
Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_5
Abstract: The IL-17 family in humans consists of six distinct cytokines (IL-17A-F) that can interact with five IL-17 receptors (IL-17RA-E). The interaction between these cytokines and their receptors are critical in mediating host defenses while also… read more here.
Keywords: cytokines receptors; interleukin family; structural insights; family ... See more keywords
Structural insights into SMCR8 C-degron recognition by FEM1B.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.046
Abstract: C-degrons play critical roles in targeting the receptor proteins of Cullin-RING E3 ligase complexes to initiate protein degradation. FEM1 proteins, including FEM1A, FEM1B, and FEM1C, act as the receptors to specifically recognize Arg/C-degrons to enable… read more here.
Keywords: insights smcr8; degron; smcr8 degron; structural insights ... See more keywords
Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Chemistry"
DOI: 10.1016/j.bpc.2016.11.011
Abstract: The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided… read more here.
Keywords: function nuclease; cdc45; structural insights; cdc45 function ... See more keywords
Structural insights into the gating mechanisms of TRPV channels.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102168
Abstract: Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in… read more here.
Keywords: trpv channels; trpv; structural insights; gating mechanisms ... See more keywords
Structural Insights into the Mammalian Late-Stage Initiation Complexes
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.03.061
Abstract: Summary In higher eukaryotes, the mRNA sequence in the direct vicinity of the start codon, called the Kozak sequence (CRCCaugG, where R is a purine), is known to influence the rate of the initiation process.… read more here.
Keywords: late stage; initiation complexes; initiation; structural insights ... See more keywords
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107909
Abstract: SUMMARY Sprouty-related, EVH1 domain-containing (SPRED) proteins negatively regulate RAS/mitogen-activated protein kinase (MAPK) signaling following growth factor stimulation. This inhibition of RAS is thought to occur primarily through SPRED1 binding and recruitment of neurofibromin, a RasGAP,… read more here.
Keywords: spred1 neurofibromin; insights spred1; structural insights; oncogenic egfr ... See more keywords
Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109619
Abstract: SUMMARY G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative… read more here.
Keywords: modulation; structural insights; cholesterol; channel ... See more keywords
Unraveling structural insights of ribokinase from Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.001
Abstract: Ribokinase (RK) is an ATP dependent sugar kinase that enables the entry of ribose in the metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of nucleosides and by transport from the extracellular environment. Activation… read more here.
Keywords: unraveling structural; structural insights; insights ribokinase; donovani ... See more keywords