Biochemical and structural insights into an allelic variant causing the lysosomal storage disorder – aspartylglucosaminuria
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13190
Abstract: Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by defects of the hydrolase glycosylasparaginase (GA). Previously, we showed that a Canadian AGU mutation disrupts an obligatory intramolecular autoprocessing with the enzyme trapped as an inactive… read more here.
Keywords: lysosomal storage; storage disorder; biochemical structural; structural insights ... See more keywords
Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202406230
Abstract: G‐quadruplex (G4) structures play important roles in various biological processes, especially the gene regulation. Nucleolar protein 56 (NOP56) is an essential component in ribosome biogenesis while its overexpression associates with various types of cancers, rendering… read more here.
Keywords: antiparallel chair; intron nop56; structure; chair type ... See more keywords
Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202508924
Abstract: Polyphenols hold significant promise in pharmaceutical, biotechnology, and food‐related applications owing to their potent free radical scavenging, antimicrobial, antitumor, and other properties. The unique chemical architecture, featuring multiple phenolic hydroxyl groups and aromatic ring systems‐confers… read more here.
Keywords: materials structural; based functional; functional materials; structural insights ... See more keywords
Structural insights into anticancer activity of D-ring modified estrone derivatives using their lipophilicity in estimation of SAR and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2242
Abstract: Many forms of breast carcinoma are hormone-dependent and therefore development of novel aromatase inhibitors is of particular interest. Since brain metastases are frequent in patients with advanced breast carcinoma, one of the goals of modern… read more here.
Keywords: docking studies; analysis; lipophilicity; structural insights ... See more keywords
Structural Insights into the Hydrogen-Bonding and Folding Pattern in Ant-Ant-Pro-Gly Tetrapeptides
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700181
Abstract: In this paper, we provide structural insights into the hydrogen-bonding and folding pattern in Ant-Ant-Pro-Gly tetrapeptides (Ant: anthranilic acid; Pro: proline; and Gly: glycine). Comparison of the C-terminal esters and their amide analogs revealed strikingly… read more here.
Keywords: folding pattern; insights hydrogen; structural insights; bonding folding ... See more keywords
Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_5
Abstract: The IL-17 family in humans consists of six distinct cytokines (IL-17A-F) that can interact with five IL-17 receptors (IL-17RA-E). The interaction between these cytokines and their receptors are critical in mediating host defenses while also… read more here.
Keywords: cytokines receptors; interleukin family; structural insights; family ... See more keywords
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Sign Up to like & getrecommendations! Published in 2024 at "Amino Acids"
DOI: 10.1007/s00726-023-03367-1
Abstract: Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has… read more here.
Keywords: binding; active site; structural insights; potential binding ... See more keywords
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
Sign Up to like & getrecommendations! Published in 2024 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-024-00442-2
Abstract: Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance. In this study, we isolated and identified 21 bufadienolides from the gallbladders of Bufo gargarizans , comprising… read more here.
Keywords: insights biotransformation; hydroxybufadienolides bufo; biotransformation; gallbladders structural ... See more keywords
Structural insights into SMCR8 C-degron recognition by FEM1B.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.046
Abstract: C-degrons play critical roles in targeting the receptor proteins of Cullin-RING E3 ligase complexes to initiate protein degradation. FEM1 proteins, including FEM1A, FEM1B, and FEM1C, act as the receptors to specifically recognize Arg/C-degrons to enable… read more here.
Keywords: insights smcr8; degron; smcr8 degron; structural insights ... See more keywords
Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Chemistry"
DOI: 10.1016/j.bpc.2016.11.011
Abstract: The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided… read more here.
Keywords: function nuclease; cdc45; structural insights; cdc45 function ... See more keywords
Structural insights into the gating mechanisms of TRPV channels.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102168
Abstract: Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in… read more here.
Keywords: trpv channels; trpv; structural insights; gating mechanisms ... See more keywords