Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113980
Abstract: Human Cathepsin A (CatA) is a lysosomal serine carboxypeptidase of the renin-angiotensin system (RAS) and is structurally similar to acetylcholinesterase (AChE). CatA can remove the C-terminal amino acids of endothelin I, angiotensin I, Substance P,… read more here.
Keywords: structural kinetic; human cathepsin; inhibition; ache cata ... See more keywords
Structural, kinetic and operational characterization of an immobilized l-aminoacid dehydrogenase
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2017.03.005
Abstract: Abstract l -Alanine dehydrogenase from Bacillus subtillis is a NADH-dependent enzyme that catalyzes the reversible reductive amination of pyruvate using ammonia as amine source. This enzyme has been intensively exploited in biocatalysis but its immobilized… read more here.
Keywords: characterization immobilized; kinetic operational; structural kinetic; immobilized enzyme ... See more keywords
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c03260
Abstract: Oligomers comprised of misfolded proteins are implicated as neurotoxins in the pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's diseases. Structural, biophysical, and biochemical characterization of these nanoscale protein assemblies is key to… read more here.
Keywords: synuclein; structural kinetic; analysis; synuclein oligomers ... See more keywords
Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24501-0
Abstract: Aducanumab, a human-derived antibody targeting amyloid-β (Aβ), is in Phase 3 clinical trials for the treatment of Alzheimer’s disease. Biochemical and structural analyses show that aducanumab binds a linear epitope formed by amino acids 3–7… read more here.
Keywords: structural kinetic; aducanumab; kinetic basis; epitope ... See more keywords
Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052485
Abstract: Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest questions… read more here.
Keywords: protein folding; molecular chaperones; structural kinetic; multidomain protein ... See more keywords
Fundamental Structural and Kinetic Principals of High Strength UHMWPE Fibers Production by Gel-Technology
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DOI: 10.3390/polym14214771
Abstract: One of the main research work in the field of polymeric materials was, is and always will be the improvement of their mechanical properties. Comprehensive structural studies of UHMWPE reactor powder, the features of its… read more here.
Keywords: strength; kinetic principals; structural kinetic; uhmwpe films ... See more keywords