Structural Mechanism of Barriers to Interspecies Seeding Transmissibility of Full‐Length Prion Protein Amyloid
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900218
Abstract: A puzzling feature of prion diseases is the cross‐species barriers. The detailed molecular mechanisms underlying these interspecies barriers remain poorly understood because of a lack of high‐resolution structural information on the scrapie isoform of the… read more here.
Keywords: 165 167; structural mechanism; prion; prion protein ... See more keywords
Structural mechanism of arrestin activation.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.05.001
Abstract: The large and multifunctional family of G protein-coupled receptors (GPCRs) are regulated by a small family of structurally conserved arrestin proteins. In order to bind an active GPCR, arrestin must first be activated by interaction… read more here.
Keywords: arrestin activation; active gpcr; structural mechanism; mechanism arrestin ... See more keywords
Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.
Sign Up to like & getrecommendations! Published in 2020 at "Science advances"
DOI: 10.1126/sciadv.abb2964
Abstract: Mutations in ryanodine receptors (RyRs), intracellular Ca2+ channels, are associated with deadly disorders. Despite abundant functional studies, the molecular mechanism of RyR malfunction remains elusive. We studied two single-point mutations at an equivalent site in… read more here.
Keywords: mutations equivalent; structural mechanism; site; equivalent site ... See more keywords
Structural mechanism of extranucleosomal DNA readout by the INO80 complex
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add3189
Abstract: The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene regulatory elements, which is proposed to be the result of an… read more here.
Keywords: ino80; dna; structural mechanism; extranucleosomal dna ... See more keywords
Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
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DOI: 10.15252/embr.202153233
Abstract: TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly expressed in skin keratinocytes and has been implicated in cutaneous sensation and associated with numerous skin pathologies and cancers. TRPV3 is inhibited by… read more here.
Keywords: structural mechanism; mechanism trpv3; inhibition; channel inhibition ... See more keywords
Structural mechanism of TAF-Iβ chaperone function on linker histone H1.10.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.2139/ssrn.4106200
Abstract: Linker histone H1, facilitated by its chaperones, plays an essential role in regulating gene expression by maintaining chromatin's higher-order structure and epigenetic state. However, we know little about the structural mechanism of how the chaperones… read more here.
Keywords: linker; taf; structural mechanism; linker histone ... See more keywords