Structural Mechanisms of the Cooling Rate Effect on the Deformation Behaviors in Metallic Glasses
Sign Up to like & getrecommendations! Published in 2019 at "Metals and Materials International"
DOI: 10.1007/s12540-019-00513-x
Abstract: Abstract In this work, the structural mechanisms of the cooling rate effect on the deformation behaviors in metallic glasses (MGs) is studied, by performing the synchrotron radiation-based experiments coupled with a series of simulations. It… read more here.
Keywords: mechanisms cooling; structural mechanisms; deformation; rate effect ... See more keywords
Structural Mechanisms of Mechanosensitivity in the TREK-2 K2P Potassium Channel
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.073
Abstract: Mechanosensitive ion channels are gated open and shut by changes in membrane tension enabling the conversion of mechanical stimuli into changes in ionic composition and electrical signalling. However, the precise structural and biophysical mechanisms underlying… read more here.
Keywords: mechanisms mechanosensitivity; mechanosensitivity trek; k2p potassium; structural mechanisms ... See more keywords
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.002
Abstract: Mutations in ATP13A2, also known as PARK9, cause a rare monogenic form of juvenile-onset Parkinson's disease named Kufor-Rakeb syndrome and other neurodegenerative diseases. ATP13A2 encodes a neuroprotective P5B P-type ATPase highly enriched in the brain… read more here.
Keywords: gating ion; structural mechanisms; polyamine; ion ... See more keywords
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45466
Abstract: Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been used as pharmacological probes and investigated as drug leads for nAChR… read more here.
Keywords: conotoxin activity; structural mechanisms; nicotinic acetylcholine; conotoxin ... See more keywords
SAT-040 Structural Mechanisms of Parathyroid Hormone (PTH) Binding to Receptor and Regulation of Endosomal Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-040
Abstract: Abstract The parathyroid hormone (PTH) type 1 receptor (PTHR) is a key regulator of bone turnover and calcium homeostasis. PTHR primarily activates the stimulatory G-protein, Gs, for adenylate cyclases that induce the production of cAMP.… read more here.
Keywords: terminal half; hinge; pth; receptor ... See more keywords
Structural mechanisms of HECT-type ubiquitin ligases
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2017-0184
Abstract: Abstract Ubiquitin ligases (E3 enzymes) transfer ubiquitin from ubiquitin-conjugating (E2) enzymes to target proteins. By determining the selection of target proteins, modification sites on those target proteins, and the types of ubiquitin modifications that are… read more here.
Keywords: hect enzymes; structural mechanisms; ubiquitin ligases; mechanisms hect ... See more keywords
Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.900560
Abstract: Hedgehog (Hh) signaling plays pivotal roles in embryonic development. In adults, Hh signaling is mostly turned off but its abnormal activation is involved in many types of cancer. Hh signaling is initiated by the Hh… read more here.
Keywords: structural mechanisms; autoprocessing structural; hedgehog autoprocessing; drug discovery ... See more keywords
Seeing Structural Mechanisms of Optimized Piezoelectric and Thermoelectric Bulk Materials through Structural Defect Engineering
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15020487
Abstract: Aberration-corrected scanning transmission electron microscopy (AC-STEM) has evolved into the most powerful characterization and manufacturing platform for all materials, especially functional materials with complex structural characteristics that respond dynamically to external fields. It has become… read more here.
Keywords: structural mechanisms; mechanisms optimized; defect engineering; functional materials ... See more keywords
Structural mechanisms of phospholipid activation of the human TPC2 channel
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.45222
Abstract: Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand-bound and apo states. The apo… read more here.
Keywords: human tpc2; mechanisms phospholipid; phospholipid activation; structural mechanisms ... See more keywords