Structural and mechanistic insights into modified G-quadruplex thrombin-binding DNA aptamers.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.025
Abstract: Thrombin-binding aptamer (TBA) can fold into a G-quadruplex structure necessary for interacting with thrombin. When one thymidine residue of the TGT loop at position 7 is replaced with unlocked uracil (UNA), d-isothymidine (D-isoT) or l-isothymidine… read more here.
Keywords: structural mechanistic; isot una; thrombin; insights modified ... See more keywords
Structural and Mechanistic Insights into Caffeine Degradation by the Bacterial N-Demethylase Complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.08.004
Abstract: Caffeine, found in many foods, beverages, and pharmaceuticals, is the most used chemical compound for mental alertness. It is originally a natural product of plants and exists widely in environmental soil. Some bacteria, such as… read more here.
Keywords: degradation; structural mechanistic; degradation bacterial; caffeine degradation ... See more keywords
Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.02.014
Abstract: With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering the lack of economic prospects for investment in this field, approaches aiming… read more here.
Keywords: tropical infectious; insight antiviral; mechanistic insight; infectious diseases ... See more keywords
Structural and mechanistic elucidation of inflammasome signaling by cryo-EM.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.03.033
Abstract: The innate immune system forms an evolutionarily ancient line of defense against invading pathogens and endogenous danger signals. Within certain cells of innate immunity, including epithelial cells and macrophages, intricate molecular machineries named inflammasomes sense… read more here.
Keywords: elucidation inflammasome; mechanistic elucidation; inflammasome signaling; structural mechanistic ... See more keywords
Monobodies as enabling tools for structural and mechanistic biology.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.01.015
Abstract: Monobodies, built with the scaffold of the fibronectin type III domain, are among the most well-established synthetic binding proteins. They promote crystallization of challenging molecular systems. They have strong tendency to bind to functional sites… read more here.
Keywords: monobodies enabling; tools structural; enabling tools; structural mechanistic ... See more keywords
Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.2c00210
Abstract: The oral antiparasitic drug nifurtimox has been used to treat Chagas disease for more than 50 years. Historical studies determined that very little nifurtimox is excreted unchanged, but contemporaneous preclinical studies of radiolabeled nifurtimox found… read more here.
Keywords: metabolism nifurtimox; metabolism; structural mechanistic; mechanistic investigation ... See more keywords
Structural and mechanistic basis of the inhibitory potency of selected 2-aminothiazole compounds on protein kinase CK2.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00587
Abstract: Selective inhibitors of protein kinase CK2 with significant cytotoxicity on tumor cells based on a 2-aminothiazole scaffold were described recently. Here, these studies are supplemented with representative CK2α/CK2α' complex struc-tures. They reveal that the 2-aminothiazole-based… read more here.
Keywords: kinase ck2; structural mechanistic; mechanistic basis; protein kinase ... See more keywords
Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00742
Abstract: Numerous aromatic compounds are aerobically degraded in bacteria via the central intermediate phenylacetic acid (paa). In one of the key steps of this widespread catabolic pathway, 1,2-epoxyphenylacetyl-CoA is converted by PaaG into the heterocyclic oxepin-CoA.… read more here.
Keywords: structural mechanistic; oxepin coa; mechanistic basis; coa ... See more keywords
Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/nmicrobiol.2017.35
Abstract: Argonaute (Ago) proteins in eukaryotes are known as key players in post-transcriptional gene silencing1, while recent studies on prokaryotic Agos hint at their role in the protection against invading DNA2,3. Here, we present crystal structures… read more here.
Keywords: dna; archaeal dna; structural mechanistic; insights archaeal ... See more keywords
Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18464-y
Abstract: O-Acetylation of the capsular polysaccharide (CPS) of Neisseria meningitidis serogroup A (NmA) is critical for the induction of functional immune responses, making this modification mandatory for CPS-based anti-NmA vaccines. Using comprehensive NMR studies, we demonstrate… read more here.
Keywords: acetylation; capsule; structural mechanistic; mechanistic basis ... See more keywords
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-0544-7
Abstract: Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane.… read more here.
Keywords: akba; insights lipoxygenase; inhibition; structural mechanistic ... See more keywords