Broad-spectrum rescue compounds for structural p53 mutations: perspective on ‘Arsenic trioxide rescues structural p53 mutations through a cryptic allosteric site’
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DOI: 10.1093/jmcb/mjab007
Abstract: Precision medicine targeting gene mutations holds the promise of changing the landscape of cancer care and prognosis, but currently approved drugs in this category are efficacious in only a very small percentage of all cancer… read more here.
Keywords: p53 mutations; structural p53; mutant p53; p53 ... See more keywords