IMCR coupled one-pot process: Efficient tools to Diversity-Oriented Synthesis of structural peptidomimetics containing heterocyclic bioisosteres and DFT conformational studies.
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DOI: 10.1002/cplu.202300633
Abstract: Multicomponent diversity-oriented synthesis (DOS) of conformationally anchored structural peptidomimetics like 2,5-diketopiperazines (2,5-DKP) containing heterocyclic bioisosteres of the amide bond, such as 1,2,3-triazoles and 1,5-disubstituted tetrazoles (1,5-DS-T) is described. Structural peptidomimetics are synthesized from similar available starting… read more here.
Keywords: diversity oriented; structural peptidomimetics; heterocyclic bioisosteres; oriented synthesis ... See more keywords