SPRDA: a link prediction approach based on the structural perturbation to infer disease-associated Piwi-interacting RNAs
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac498
Abstract: piRNA and PIWI proteins have been confirmed for disease diagnosis and treatment as novel biomarkers due to its abnormal expression in various cancers. However, the current research is not strong enough to further clarify the… read more here.
Keywords: structural perturbation; based structural; disease; sprda ... See more keywords
SPCMLMI: A structural perturbation-based matrix completion method to predict lncRNA–miRNA interactions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1032428
Abstract: Accumulating evidence indicated that the interaction between lncRNA and miRNA is crucial for gene regulation, which can regulate gene transcription, further affecting the occurrence and development of many complex diseases. Accurate identification of interactions between… read more here.
Keywords: matrix completion; structural perturbation; similarity; mirna interactions ... See more keywords
Probing Structural Perturbation of Biomolecules by Extracting Cryo-EM Data Heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050628
Abstract: Single-particle cryogenic electron microscopy (cryo-EM) has become an indispensable tool to probe high-resolution structural detail of biomolecules. It enables direct visualization of the biomolecules and opens a possibility for averaging molecular images to reconstruct a… read more here.
Keywords: probing structural; heterogeneity; structural perturbation; data heterogeneity ... See more keywords