LAUSR

Structural pharmacological studies on EGFR T790M/C797S.

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1 Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.04.138

Abstract: Drug-resistance is a major challenge in targeted therapy of EGFR mutated non-small cell lung cancers (NSCLCs). The third-generation irreversible inhibitors such as AZD9291, CO-1686 and WZ4002 can overcome EGFR T790M drug-resistance mutant through covalent binding… read more here.

Keywords: structural pharmacological; egfr t790m; pharmacological studies; t790m c797s ... See more keywords