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   Articles with "structural protein" as a keyword



Purification of Dengue and Zika Virus Non-structural Protein 5 for Crystallization and Screening of Antivirals.

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recommendations! Published in 2022 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1879-0_5

Abstract: Dengue Virus (DENV) and ZIKA Virus (ZIKV) are two important human pathogens that belong to the Flavivirus genus of positive strand RNA viruses. Symptoms of DENV infections range from asymptomatic or mild fever to life-threatening… read more here.

Keywords: protein; structural protein; non structural; dengue ... See more keywords

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101258

Abstract: Summary Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate viral replication, overall virulence and… read more here.

Keywords: structural protein; protein nsp9; non structural; structure ... See more keywords

The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach.

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recommendations! Published in 2017 at "Journal of proteomics"

DOI: 10.1016/j.jprot.2016.11.001

Abstract: Dengue is an important mosquito borne viral disease in the world. Dengue virus (DENV) encodes a polyprotein, which is cleaved in ten proteins, including the non-structural protein 1 (NS1). In this work, we analyzed the… read more here.

Keywords: protein; structural protein; hepg2; non structural ... See more keywords

Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals.

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recommendations! Published in 2019 at "Research in veterinary science"

DOI: 10.1016/j.rvsc.2019.03.015

Abstract: Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of cloven-hoofed animals. Vaccination is a key element in the control of FMD among countries where the disease is enzootic. Differentiating infected from… read more here.

Keywords: protein; structural protein; non structural; disease ... See more keywords

Human single chain-transbodies that bound to domain-I of non-structural protein 5A (NS5A) of hepatitis C virus

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-14886-9

Abstract: A safe and broadly effective direct acting anti-hepatitis C virus (HCV) agent that can withstand the viral mutation is needed. In this study, human single chain antibody variable fragments (HuscFvs) to conserved non-structural protein-5A (NS5A)… read more here.

Keywords: protein; structural protein; human single; non structural ... See more keywords

Glycans on non-structural protein 1 prevent premature T-cell mediated dengue virus clearance

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recommendations! Published in 2025 at "EMBO Molecular Medicine"

DOI: 10.1038/s44321-025-00311-6

Abstract: Non-structural protein 1 (NS1) of dengue virus (DENV) harbours two conserved N-glycosylation sites at positions 130 and 207, whose biological roles have remained elusive. Using a clinically relevant mouse model of severe dengue, we showed… read more here.

Keywords: denv; non structural; clearance; cell mediated ... See more keywords

Dynamics and allostery of Zika virus non-structural protein 5 methyltransferase

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recommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2020.1792343

Abstract: Abstract The methyltransferase (MTase) domain of non-structural protein 5 (NS5) plays a fundamental role in flaviviruses replication, and its inhibition is a strategy for antiviral development. MTase methylates viral RNA cap at guanine N-7 and… read more here.

Keywords: structural protein; non structural; methyltransferase; zika virus ... See more keywords

Exploration of comprehensive marine natural products database against dengue viral non-structural protein 1 using high-throughput computational studies

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recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2023.2297006

Abstract: Abstract Dengue virus (DENV) non-structural protein 1 (NS1) is a versatile quasi-protein essential for the multiplication of the virus. This study applied high-throughput virtual screening (HTVS) and molecular dynamics (MD) simulation to detect the potential… read more here.

Keywords: high throughput; marine natural; non structural; protein ... See more keywords

False-positive dengue non-structural protein 1 in pregnancy

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recommendations! Published in 2024 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"

DOI: 10.1093/trstmh/trae134

Abstract: Abstract Dengue is a vector-borne infection, which contributes to significant morbidity and mortality in endemic areas. It manifests rapidly within 2 wk from febrile, critical to recovery phase. The point-of-care test (POCT) comprises the non-structural… read more here.

Keywords: dengue; false positive; non structural; pregnancy ... See more keywords

Autophagy and evasion of the immune system by SARS-CoV-2. Structural features of the non-structural protein 6 from wild type and Omicron viral strains interacting with a model lipid bilayer

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recommendations! Published in 2022 at "Chemical Science"

DOI: 10.1101/2022.01.05.475107

Abstract: The viral cycle of SARS-CoV-2 is based on a complex interplay with the cellular machinery, which is mediated by specific proteins eluding or hijacking the cellular defense mechanisms. Among the complex pathways called by the… read more here.

Keywords: structural protein; non structural; lipid bilayer; sars cov ... See more keywords

Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response

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recommendations! Published in 2023 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.04138-22

Abstract: EV-D68 is a globally emerging pathogen that causes severe respiratory illnesses. Here, we report that EV-D68 inhibits innate immune responses by targeting IRF7. Further investigations revealed that the structural protein VP3 inhibited the TRAF6-induced ubiquitination… read more here.

Keywords: vp3; interaction; d68; structural protein ... See more keywords