Purification of Dengue and Zika Virus Non-structural Protein 5 for Crystallization and Screening of Antivirals.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1879-0_5
Abstract: Dengue Virus (DENV) and ZIKA Virus (ZIKV) are two important human pathogens that belong to the Flavivirus genus of positive strand RNA viruses. Symptoms of DENV infections range from asymptomatic or mild fever to life-threatening… read more here.
Keywords: protein; structural protein; non structural; dengue ... See more keywords
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101258
Abstract: Summary Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate viral replication, overall virulence and… read more here.
Keywords: structural protein; protein nsp9; non structural; structure ... See more keywords
The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2016.11.001
Abstract: Dengue is an important mosquito borne viral disease in the world. Dengue virus (DENV) encodes a polyprotein, which is cleaved in ten proteins, including the non-structural protein 1 (NS1). In this work, we analyzed the… read more here.
Keywords: protein; structural protein; hepg2; non structural ... See more keywords
Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals.
Sign Up to like & getrecommendations! Published in 2019 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2019.03.015
Abstract: Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of cloven-hoofed animals. Vaccination is a key element in the control of FMD among countries where the disease is enzootic. Differentiating infected from… read more here.
Keywords: protein; structural protein; non structural; disease ... See more keywords
Human single chain-transbodies that bound to domain-I of non-structural protein 5A (NS5A) of hepatitis C virus
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14886-9
Abstract: A safe and broadly effective direct acting anti-hepatitis C virus (HCV) agent that can withstand the viral mutation is needed. In this study, human single chain antibody variable fragments (HuscFvs) to conserved non-structural protein-5A (NS5A)… read more here.
Keywords: protein; structural protein; human single; non structural ... See more keywords
Dynamics and allostery of Zika virus non-structural protein 5 methyltransferase
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1792343
Abstract: Abstract The methyltransferase (MTase) domain of non-structural protein 5 (NS5) plays a fundamental role in flaviviruses replication, and its inhibition is a strategy for antiviral development. MTase methylates viral RNA cap at guanine N-7 and… read more here.
Keywords: structural protein; non structural; methyltransferase; zika virus ... See more keywords
Autophagy and evasion of the immune system by SARS-CoV-2. Structural features of the non-structural protein 6 from wild type and Omicron viral strains interacting with a model lipid bilayer
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1101/2022.01.05.475107
Abstract: The viral cycle of SARS-CoV-2 is based on a complex interplay with the cellular machinery, which is mediated by specific proteins eluding or hijacking the cellular defense mechanisms. Among the complex pathways called by the… read more here.
Keywords: structural protein; non structural; lipid bilayer; sars cov ... See more keywords
Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04138-22
Abstract: EV-D68 is a globally emerging pathogen that causes severe respiratory illnesses. Here, we report that EV-D68 inhibits innate immune responses by targeting IRF7. Further investigations revealed that the structural protein VP3 inhibited the TRAF6-induced ubiquitination… read more here.
Keywords: vp3; interaction; d68; structural protein ... See more keywords
Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266136
Abstract: Non-structural protein 1 (NS1) is a glycoprotein component of dengue virus (DENV) that is essential for viral replication, infection and immune evasion. Immunization with NS1 has been shown to elicit antibody-mediated immune responses which protect… read more here.
Keywords: structural protein; protein ns1; dengue; non structural ... See more keywords
Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host–Pathogen Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.574067
Abstract: Dengue is emerging as one of the most prevalent mosquito-borne viral diseases of humans. The 11kb RNA genome of the dengue virus encodes three structural proteins (envelope, pre-membrane, capsid) and seven non-structural proteins (NS1, NS2A,… read more here.
Keywords: dengue virus; structural protein; non structural; host ... See more keywords
The Dual Role of the Antibody Response Against the Flavivirus Non-structural Protein 1 (NS1) in Protection and Immuno-Pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01651
Abstract: Dengue and Zika viruses are closely related mosquito-borne flaviviruses responsible for major public health problems in tropical and sub-tropical countries. The genomes of both, dengue and zika viruses encodes 10 genes that are translated into… read more here.
Keywords: protein; structural protein; protein ns1; dengue zika ... See more keywords