The impact of patient, embryo, and translocation characteristics on the ploidy status of young couples undergoing preimplantation genetic testing for structural rearrangements (PGT-SR) by next generation sequencing (NGS)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-02054-4
Abstract: Purpose To evaluate the factors that affect the incidence of euploid balanced embryos and interchromosomal effect (ICE) in carriers of different structural rearrangements. Methods This retrospective study includes 95 couples with reciprocal translocations (RecT) and… read more here.
Keywords: rect carriers; undergoing preimplantation; structural rearrangements; embryo ... See more keywords
Validation of concurrent preimplantation genetic testing for polygenic and monogenic disorders, structural rearrangements, and whole and segmental chromosome aneuploidy with a single universal platform.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2019.04.004
Abstract: Preimplantation genetic testing (PGT) has been successfully applied to reduce the risk of miscarriage, improve IVF success rates, and prevent inheritance of monogenic disease and unbalanced translocations. The present study provides the first method capable… read more here.
Keywords: genetic testing; structural rearrangements; aneuploidy; platform ... See more keywords
Necessity of structural rearrangements for O O bond formation between O5 and W2 in photosystem II
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Energy Chemistry"
DOI: 10.1016/j.jechem.2020.09.008
Abstract: Abstract Numerous aspects of the water oxidation mechanism in photosystem II have not been fully elucidated, especially the O-O bond formation pathway. However, a body of experimental evidences have identified the O5 and W2 ligands… read more here.
Keywords: bond formation; structural rearrangements; photosystem; formation ... See more keywords
Structural rearrangements of the histone octamer translocate DNA
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03677-z
Abstract: Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP-dependent remodeling factors. Yet, the mechanism of DNA translocation around the… read more here.
Keywords: dna; structural rearrangements; rearrangements histone; histone octamer ... See more keywords
Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33390-2
Abstract: The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. Importantly, glycan N301 shields V3… read more here.
Keywords: structural rearrangements; hiv envelope; rearrangements maintain; glycan shield ... See more keywords
Multiple structural rearrangements mediated by high-plasticity regions in Atg3 are key for efficient conjugation of Atg8 to PE during autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1954457
Abstract: ABSTRACT The Atg3 protein is highly homologous from yeast to human. Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during… read more here.
Keywords: autophagy multiple; structural rearrangements; conjugation atg8; autophagy ... See more keywords
Evidence of structural rearrangements in ESBL-positive pESI(like) megaplasmids of S.Infantis
Sign Up to like & getrecommendations! Published in 2023 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnad014
Abstract: Abstract The increasing prevalence of pESI(like)-positive, multidrug-resistant (MDR) S. Infantis in Europe is a cause of major concern. As previously demonstrated, the pESI(like) megaplasmid is not only a carrier of antimicrobial resistant (AMR) genes (at… read more here.
Keywords: esbl positive; pesi like; structural rearrangements; pesi ... See more keywords
Structural rearrangements in mRNA upon its binding to human 80S ribosomes revealed by EPR spectroscopy
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1136
Abstract: Abstract The model mRNA (MR), 11-mer RNA containing two nitroxide spin labels at the 5′- and 3′-terminal nucleotides and prone to form a stable homodimer (MR)2, was used for Electron Paramagnetic Resonance study of structural… read more here.
Keywords: rearrangements mrna; upon binding; structural rearrangements; binding human ... See more keywords
Structural rearrangements governing Johari-Goldstein relaxations in metallic glasses
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1701577
Abstract: Atomistic simulations reveal that secondary relaxations in metallic glasses originate from string-like atomic motions. The Johari-Goldstein secondary (β) relaxations are an intrinsic feature of supercooled liquids and glasses. They are crucial to many properties of… read more here.
Keywords: johari goldstein; relaxations metallic; structural rearrangements; metallic glasses ... See more keywords
Frequent spontaneous structural rearrangements promote rapid genome diversification in a Brassica napus F1 generation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1057953
Abstract: In a cross between two homozygous Brassica napus plants of synthetic and natural origin, we demonstrate that novel structural genome variants from the synthetic parent cause immediate genome diversification among F1 offspring. Long read sequencing… read more here.
Keywords: structural rearrangements; genome diversification; brassica napus; spontaneous structural ... See more keywords
Identification of Recurrent Chromosome Breaks Underlying Structural Rearrangements in Mammary Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13071228
Abstract: Cancer genomes are characterized by the accumulation of small-scale somatic mutations as well as large-scale chromosomal deletions, amplifications, and complex structural rearrangements. This characteristic is at least partially dependent on the ability of cancer cells… read more here.
Keywords: cell; recurrent chromosome; structural rearrangements; identification ... See more keywords