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Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.08.056
Abstract: Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan…
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Keywords:
structural requirements;
heparin;
minimum structural;
bmp binding ... See more keywords
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Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131148
Abstract: Abstract Protein Kinase C ζ (PKCζ) has emerged as a promising novel drug target for the treatment of arthritis. A series of isoquinoline PKCζ inhibitors were analyzed through CoMFA, CoMSIA, homology modeling, and molecular docking…
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Keywords:
structural requirements;
homology modeling;
insights structural;
pkc inhibitors ... See more keywords
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Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00028
Abstract: In contrast to artificial molecules, natural photosensitizers have the benefit of excellent toxicity profiles and of life-compatible activating energy ranges. Flavins are such photosensitizers that were selected by nature in a plethora of light-triggered biochemical…
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Keywords:
structural requirements;
nanobombs key;
conjugated nanobombs;
key structural ... See more keywords
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Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01104
Abstract: Currently, antibodies are widely used not only in research but also in therapy. Hence, peptides that selectively bind to the fragment crystallizable site of an antibody have been extensively utilized in various research efforts such…
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Keywords:
structural requirements;
binding peptides;
requirements human;
human immunoglobulin ... See more keywords
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97368-3
Abstract: Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is…
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Keywords:
structural requirements;
kinase;
exploration structural;
aurora kinase ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15121579
Abstract: Searching for bioactive compounds within the huge chemical space is like trying to find a needle in a haystack. Isatin is a unique natural compound which is endowed with different bio-pertinent activities, especially in cancer…
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Keywords:
requirements isatin;
myeloid leukemia;
acute myeloid;
insights structural ... See more keywords