Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code
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DOI: 10.1093/nar/gkab533
Abstract: Abstract The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and instead is postulated to require a multitude of features embedded in the pre-mRNA strand. We… read more here.
Keywords: spliceosomal components; structural scaffold; early spliceosomal; splicing code ... See more keywords
Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac636
Abstract: We recently reported that serine-arginine-rich (SR) protein-mediated pre-mRNA structural remodeling generates a pre-mRNA 3D structural scaffold that is stably recognized by the early spliceosomal components. However, the intermediate steps between the free pre-mRNA and the… read more here.
Keywords: pre mrna; snrnp; mrna structural; structural scaffold ... See more keywords