Structural States of RORγt: X‐ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds
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DOI: 10.1002/cmdc.201700278
Abstract: The T‐cell‐specific retinoic acid receptor (RAR)‐related orphan receptor‐γ (RORγt) is a key transcription factor for the production of pro‐inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years, several structurally… read more here.
Keywords: natural synthetic; synthetic compounds; inverse agonists; structural states ... See more keywords
The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis
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DOI: 10.3390/biom12111610
Abstract: Alternative splicing is an important means of generating the protein diversity necessary for cellular functions. Hence, there is a growing interest in assessing the structural and functional impact of alternative protein isoforms. Typically, experimental studies… read more here.
Keywords: difference structural; structural states; proteins isoforms; canonical proteins ... See more keywords